NDLI: Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris

Content Provider	Springer Nature : BioMed Central
Author	Obistioiu, Diana Cristina, Romeo T Schmerold, Ivo Chizzola, Remigius Stolze, Klaus Nichita, Ileana Chiurciu, Viorica
Abstract	Background A large number of essential oils is reported to have significant activity against Candida albicans. But the different chemical composition influences the degree of their activity. The intention of this study was to investigate the chemical composition and the activity against Candida albicans of volatile oils obtained from Artemisia dracunculus, A. abrotanum, A. absinthium and A. vulgaris (Asteraceae). The aim of the study was to identify new chemical compounds that have effect against C. albicans. The essential oils were obtained by hydrodistillation or extraction with dichloromethane (a new procedure we developed trying to obtain better, more separated compounds) from air dried above ground plant material and analyzed by GC-MS. Additionally commercial essential oils from the same species were tested. The Candida albicans inhibition studies were carried out by the paper disc diffusion method. Results The essential oils shared common components but presented differences in composition and showed variable antifungal activity. Davanone and derivatives thereof, compounds with silphiperfolane skeleton, estragole, davanone oil, β-thujone, sabinyl acetate, herniarin, cis-chrysanthenyl acetate, 1,8-cineol, and terpineol were the main components of Artemisia volatiles. Conclusions Among the volatile fractions tested those from A. abrotanum containing davanone or silphiperfolane derivatives showed the highest antifungal activity. The in vitro tests revealed that the Artemisia oils are promising candidates for further research to develop novel anti-candida drugs.
Related Links	https://bmcchem.biomedcentral.com/counter/pdf/10.1186/1752-153X-8-6.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1752-153X-8-6
Journal	BMC Chemistry
Issue Number	1
Volume Number	8
Language	English
Publisher	BioMed Central
Publisher Date	2014-01-29
Access Restriction	Open
Subject Keyword	Chemistry Food Science Artemisia Candida albicans Essential oils GC-MS Antifungal activity Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Chemistry
Journal Impact Factor	4.3/2023
5-Year Journal Impact Factor	4.4/2023

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