| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hoxha, Mirjam Dioni, Laura Bonzini, Matteo Pesatori, Angela Cecilia Fustinoni, Silvia Cavallo, Domenico Carugno, Michele Albetti, Benedetta Marinelli, Barbara Schwartz, Joel Bertazzi, Pier Alberto Baccarelli, Andrea |
| Abstract | Background Telomere shortening in blood leukocytes has been associated with increased morbidity and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological aging, are still largely unidentified. Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated. Methods We measured leukocyte telomere length (LTL) by real-time PCR in blood DNA from 77 traffic officers exposed to high levels of traffic pollutants and 57 office workers (referents). Airborne benzene and toluene, as tracers for traffic exposure, were measured using personal passive samplers and gas-chromatography/flame-ionization detector analysis. We used covariate-adjusted multivariable models to test the effects of the exposure on LTL and obtain adjusted LTL means and 95% Confidence Intervals (CIs). Results Adjusted mean LTL was 1.10 (95%CI 1.04-1.16) in traffic officers and 1.27 in referents (95%CI 1.20-1.35) [p < 0.001]. LTL decreased in association with age in both traffic officers (p = 0.01) and referents (p = 0.001), but traffic officers had shorter LTL within each age category. Among traffic officers, adjusted mean relative LTL was shorter in individuals working in high (n = 45, LTL = 1.02, 95%CI 0.96-1.09) compared to low traffic intensity (n = 32, LTL = 1.22, 95%CI 1.13-1.31) [p < 0.001]. In the entire study population, LTL decreased with increasing levels of personal exposure to benzene (p = 0.004) and toluene (p = 0.008). Conclusion Our results indicate that leukocyte telomere length is shortened in subjects exposed to traffic pollution, suggesting evidence of early biological aging and disease risk. |
| Related Links | https://ehjournal.biomedcentral.com/counter/pdf/10.1186/1476-069X-8-41.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/1476-069X-8-41 |
| Journal | Environmental Health |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2009-09-21 |
| Access Restriction | Open |
| Subject Keyword | Occupational Medicine Industrial Medicine Public Health Environmental Health Telomere Length Environmental Tobacco Smoke Short Telomere Leukocyte Telomere Length Traffic Pollutant Occupational Medicine/Industrial Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
| Journal Impact Factor | 5.4/2023 |
| 5-Year Journal Impact Factor | 6.7/2023 |
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