NDLI: P5.24: Pulmonary Arterial Hypertension and Arterial Stiffness

Content Provider	Springer Nature : BioMed Central
Author	Alloni, M. Vincenzi, A. Cesana, F. De Carlini, C. Villa, P. Cereda, A. Vigano, E. Canova, P. Paciocco, G. Facchetti, R. Cirò, A. Giannattasio, C. Mancia, G.
Abstract	Background Endothelium plays an important role in the development and progression of Pulmonary Arterial Hypertension (PAH), independently of its aetiology. Little is known on derived central blood pressure (CBP) and arterial stiffness in PAH. The aim of this study was to describe CBP and arterial stiffness as measured by PWA (Aix). Methods We studied 21 PAH patients; 11 were first diagnosis and not treated (PAHNT, age 58±17yrs, BP 135±33/81±16 mmHg, direct PAPc 49±13 mmHg mean±SD); 10 were under specific drugs (Calcium channel blockers, endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, prostacyclin derivatives) (PAHT, age 67±8 yrs, BP: 136±28/72 ±14 mmHg, PAPc, 42±14mmHg). 10 age and sex matched subjects served as controls (C, age 61±15 yrs, BP:130±13/77±6 mmHg). We used applanation tonometry (Sphygmocor, AtCor) to study PWA and to derive CBP and Aix, which was used as an index of arterial stiffness. Results Both systolic and diastolic CBP were similar in the three groups. On the contrary Aix was higher in PAH than in C (26 ± 7.8 vs. 19 ± 11.6%); among the two PAH groups, Aix was significantly higher in NT than in T (30±6.9 vs. 22±7.1% p<0.02). In PAH Aix showed significant correlation (p<0.05) only with BMI (r=−0.49). Conclusions Our data show that AIx is increased in PAH. They also show that it decreases in association with specific therapy. This pilot study suggests that AIx could be used in PAH as an additional non-invasive marker to assess the efficacy of therapy.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2011.10.079.pdf
Ending Page	169
Page Count	1
Starting Page	169
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2011.10.079
Journal	Artery Research
Issue Number	4
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2011-11-29
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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