NDLI: P3.05: Effects of Acetazolamide on Blood Pressure and Pulse Waveform Changes Induced by High Altitude Exposure

Content Provider	Springer Nature : BioMed Central
Author	Revera, M. Salvi, P. Giuliano, A. Bilo, G. Faini, A. Gregorini, F. Lombardi, C. Mancia, G. Parati, G.
Abstract	Background Exposure to high altitude (HA) may induce mountain sickness and increase blood pressure (BP) but little is known on the effects on arterial properties. Acetazolamide (AC) has been proposed to prevent and treat mountain sickness, but no information is available on its effects on cardiovascular parameters at HA. Our aim was to assess these issues in healthy volunteers acutely exposed to very HA. Methods 42 subjects (age 36.8±8.9, 21 Male) were randomized to double blind AC 250 mg bid or placebo (PL). Arterial tonometry (PulsePen, DiaTecne, Milan) including carotid-femoral and carotid-radial PWV (CF-PWV,CR-PWV) and pulse wave analysis (augmentation index, AIx and subendocardial viability ratio, SEVR) was performed: at baseline (BAS), after 2 days of treatment at sea level (SLpost); within 6 hours from arrival at Capanna Margherita (Mount Rosa, 4559 m,HA1); and on 3rd full day of exposure to HA(HA2). Systolic (S) and diastolic (D)BP were measured with validated oscillometric device (AND UA 767-PC). Heart rate (HR) was derived from the ECG signal. Data are shown as means±SD. Results (See table, p = peripheral, c = central, M = mean). At HA, AIx (adjusted for HR) increased but was significantly lower in AC group, moreover AC treatment partially counteracted the decrease in SEVR. Conclusions Acute exposure to HA induced both a BP rise and changes in vascular function, partly counteracted by treatment with AC. These haemodynamic effects may contribute to the beneficial role of AC at HA and may have implications for the possible clinical usefulness of AC in patients with hypoxemia.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2011.10.040.pdf
Ending Page	157
Page Count	1
Starting Page	157
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2011.10.040
Journal	Artery Research
Issue Number	4
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2011-11-29
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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