NDLI: P3.07: The Influence of Antihypertensive Treatment on Arterial Stiffness and Arterial Wall Shear Stress

Content Provider	Springer Nature : BioMed Central
Author	Rajzer, M. W. Wojciechowska, W. Klocek, M. Kawecka-Jaszcz, K.
Abstract	The aim of the study was to compare the effects of 5 drugs representing different antihypertensive classes on arterial wall shear stress (WSS) and arterial stiffness in patients with essential arterial hypertension (HT). Material and methods 95 pts. with HT (stage 1 and 2) were divided into 5 groups, (N = 19) and treated for 6 months by: quinapril 20–40 mg/d (group-1), amlodipine 5–10mg/d (group-2), hydrochlorothiazide 12,5–25mg/d (group-3), losartan 50–100 mg/d (group 4), bisoprolol 5–10 mg/d (group-5). Before and then after 1,3 and 6 months of treatment WSS in common carotid artery (CCA) was calculated using blood viscosity measured by Brookfield DV-III pro and maximal blood flow velocity measured ultrasonographically. At the same visits carotid femoral pulse wave velocity (PWV) was measured using 3 devices Complior®, Sphygmocor® and ArteriographTM, office BP was measured using Omron M5-I device. Results At the baseline no differences between groups were observed in BP, PWV, CCA- WSS. ANOVA for repeated measurements revealed for all groups during treatment period significant decrease in SBP (p<0.001), DBP (p<0.001) and PWV measured by three different devices (p<0.001). CCAWSS increased significantly (p<0.001). No between treatment groups differences were observed in above mentioned effects. In multiple regression analysis decrease of PWV was in significant relation to its baseline value (B = 0.567, p = 0.00032 and increase of CCA- WSS (B = 0.232, p = 0.0074). Conclusion Antihypertensive treatment reduces arterial stiffness proportionally to its baseline value and independently of the used drug. This effect could be partially explained by increase of arterial wall shear stress.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2011.10.042.pdf
Ending Page	158
Page Count	1
Starting Page	158
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2011.10.042
Journal	Artery Research
Issue Number	4
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2011-11-29
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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P3.07: The Influence of Antihypertensive Treatment on Arterial Stiffness and Arterial Wall Shear Stress

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