NDLI: In vitro metabolism of flucetosulfuron by artificial gastrointestinal juices

Content Provider	Springer Nature Link
Author	Moon, Joon Kwan Kim, Jeong Han Liu, Kwang Hyeon Choi, Hoon Kim, Eunhye Lee, Yong Sang
Copyright Year	2014
Abstract	To investigate the metabolism of pesticides by gastrointestinal (GI) juices, artificial GI juices were incubated with threo- and erythro-isomers of flucetosulfuron. The metabolites produced in each reaction mixture of artificial GI juices were unambiguously identified using liquid chromatography-tandem mass spectrometry. Flucetosulfuron was observed to be stable in saliva. However, in the intestinal juices, approximately 18% of flucetosulfuron was degraded, producing N-(4,6-dimethoxypyrimidin-2-ylcarbomoyl)-2-(2-fluoro-1-hydroxypropyl)pyrimidine-3-sulfonamid (M1). In artificial gastric juices, about 85% of flucetosulfuron was rapidly degraded, producing the metabolites 2-(2-fluoro-1-hydroxypropyl) pyridine-3-sulfonamide (M2), 4,6-dimethoxypyrimidin-2-amine (M3), and 2-fluoro-1-(3-sulfamoylpyridin-2-yl)propyl 2-methoxyacetate (M4). These results indicate that the sulfonylurea bridge and ester bond of flucetosulfuron are hydrolyzed in artificial GI juices. No significant differences were noted in the degradation patterns between the two isomers of flucetosulfuron in the artificial GI juices that were tested. Considering the rapid degradation of flucetosulfuron in vitro by artificial GI juices, it is likely that there would be no significant absorption of flucetosulfuron from the GI tract into the blood stream after oral administration.
Starting Page	397
Ending Page	405
Page Count	9
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	57
Issue Number	3
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2014-06-21
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	sulfonylurea flucetosulfuron Applied Microbiology Biological Techniques metabolism gastrointestinal juic Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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