NDLI: Stabilization of glabridin by chitosan nano-complex

Content Provider	Springer Nature Link
Author	Park, Hee Jun Lee, Jaegwan Park, Young Su
Copyright Year	2012
Abstract	Stabilization of glabridin, an isoflavan extracted from Glycyrrhiza glabra (licorice) root, was investigated in electrostatic complex prepared by glabridin and chitosan. Nanoparticles of the complex were spontaneously formed by adding glabridin into chitosan or three N-acylated chitosans which were synthesized by reacting chitosan with acid anhydride. N-acylated chitosans were characterized by Fourier transform infrared spectroscopy (FT-IR) and $^{1}$H-NMR. Degrees of N-acyl substitution of N-propionic, Nbutanoic, and N-hexanoic chitosan were 28.2, 34.74, and 35.02%, respectively. Transmission electron microscopy (TEM) showed the morphology of the complex particles was nano-scale spherical shape, and average size of the particles estimated by particle analyzer was between 32 and 42 nm. The electrostatic interaction between amino group of chitosan and hydroxyl group of glabridin was confirmed by the semi-doublet peak at 1590 nm$^{−1}$ in FT-IR spectra. Maximum encapsulation efficiency of glabridin was found to be 84% when N-propionic chitosan with 1% glabridin was used for the preparation of nanoparticles, and the efficiency decreased upon increasing glabridin concentration. Stability of glabridin under UV-ray was enhanced after the complex formation with chitosan, and the enhancement was further augmented when Nacylated chitosan was used instead of chitosan. Long-term stability of glabridin in aqueous solution was also affected by the complex formation, and 2.2-fold stability enhancement at 25°C after 7-day incubation was observed in the case of N-hexanoyl chitosan. Chitosan or its derivatives could be used for the stabilization of polyphenolic compound such as glabridin and applied for the development of functional cosmetic products with skin-whitening effect.
Starting Page	457
Ending Page	462
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	55
Issue Number	4
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2012-08-31
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	chitosan stabilization Applied Microbiology electrostatic interaction nanoparticle Biological Techniques glabridin Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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