NDLI: Anti-obesity Effect of Carbon Dioxide Supercritical Fluid Extracts of Panax Ginseng C. A. Meyer

Content Provider	Springer Nature Link
Author	Shin, Bok Kyu Woo, Hyun Chul Koo, Hana Cho, Inja Han, Jaehong Kim, Mihyang
Copyright Year	2011
Abstract	The root of Korean ginseng, Panax ginseng C. A. Meyer, has been known worldwide as a panacea for many centuries. Contradictory weight gain and loss effects in Korean ginseng led to the adoption of supercritical carbon dioxide extraction to assure the quality of food-grade anti-obesity ginseng products. Among different extraction conditions of CO$_{2}$ pressure (200 and 300 bars) and temperature (40, 50, and 60°C), the highest extraction yield of 0.66% was obtained with 300 bars at 40°C. To test anti-obesity effect, each supercritical fluid extract (SFE) was supplemented to the high-fat diet of male obese-prone C57BL/6J strain mice. All carbon dioxide SFEs of ginseng showed significant weight-loss effects in the tested mice. The average weights of normal and high fat diet mice were 28.7±2.0 and 35.0±1.6 g, respectively, after 10 weeks. Average weights of mice on SFE-supplemented high fat diets were between 24.5±1.4 and 25.9±1.3 g. SFEs obtained at 50°C, and at both 200 and 300 bars, showed the most profound anti-obesity effect. Both SFEs showed ~15 and ~30% weight loss for the normal and high-fat diet mice, respectively. The major component of the SFE was analyzed as polyacetylene compounds, and panaxydol and panaxynol were identified as major polyacetylene compounds. However, the anti-obesity effect of the ginseng SFEs was not correlated with contents of these two polyacetylene compounds in SFEs. No side-effects of ginseng SFEs were observed, and the anti-obesity effect was reversible.
Starting Page	738
Ending Page	743
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	54
Issue Number	5
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	supercritical fluid extraction carbon dioxide ginseng anti-obesity Applied Microbiology Biological Techniques polyacetylene Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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