NDLI: Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora

Content Provider	Springer Nature Link
Author	Baek, Nam In Shrestha, Sabina Lee, Dae Young Park, Ji Hae Chung, In Sik Seo, Woo Duck Yoo, Ki Hyun Kang, Hee Cheol Yeon, Seung Woo Cho, Jin Gyeong Jeon, Yong Jin
Copyright Year	2012
Abstract	Six biflavonoids, succedaneaflavanone (1), mesuaferrone B (2), rhusflavanone (3), rhusflavone (4), agathisflavone (5), and cupressuflavone (6), were isolated from the fruits of Rhus parviflora. The chemical structures of the compounds were determined based on NMR, fast atom bombardment mass spectrometry, and IR. Biflavonoid compounds were evaluated for cytotoxicity against human cancer cell lines, including human colon carcinoma (HCT-116), human breast carcinoma (MCF-7), and human cervical carcinoma (HeLa). Biflavonoids 2, 3, and 5 showed significant cytotoxicity with IC$_{50}$ values of 17.25 μM (mesuaferrone B against HCT-116), 17.50 μM (rhusflavone against MCF-7), and 15.20 μM (agathisflavone against HeLa). Compound 5 showed inhibition of β-secretase activity at a 10 μM concentration. Compound 6 showed inhibition of cyclin-dependent kinases (CDK2 and CDK5) with IC$_{50}$ values of 18.58 and 9.29 μM, respectively.
Starting Page	557
Ending Page	562
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	55
Issue Number	4
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2012-08-31
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	mesuaferrone B neuroprotection succedaneaflavanone agathisflavone rhusflavanone rhusflavone Applied Microbiology Biological Techniques cupressuflavone biflavonoid cytotoxicity Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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