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| Content Provider | Springer Nature Link |
|---|---|
| Author | Park, Byoung Kwon Kwon, Hyung Joo Kim, Doo Sik Kim, Dongbum Lee, Younghee Wu, Guang Choi, Song Hee |
| Copyright Year | 2014 |
| Abstract | Respiratory syncytial virus (RSV) is a common virus related to disease in the lung epithelium of young children and infants. However, RSV vaccine has not yet been developed. Thus it is difficult to develop a whole-RSV vaccine due to induction of Th2-type hyper-immune responses. To overcome this limitation, we used CpG-DNA encapsulated within liposome complex (Lipoplex(O)) as an adjuvant for the induction of a Th1-dominated humoral response in animal experiments. However, vaccination with a complex of UV-irradiated RSV and Lipoplex(O) had no effect against RSV infection. To improve the efficacy of the RSV vaccine, we performed peptide-based epitope screening and evaluated the efficacy of the vaccine using a complex of epitope and Lipoplex(O). Two efficient B-cell epitopes were identified in nine candidate epitopes from the RSV-F protein. The vaccination with a complex of RSV-F protein epitope (F7 and F9) and Lipoplex(O), induced a prophylactic effect on the RSVinfection based on lung histopathology and mucus clearance from the lungs. Thus, further studies on the effect of the peptide vaccine against infection by multiple RSV strains, may allow fine-tuning of a potential vaccine, and improvement of the vaccine program against RSV. |
| Starting Page | 667 |
| Ending Page | 676 |
| Page Count | 10 |
| File Format | |
| ISSN | 17382203 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume Number | 57 |
| Issue Number | 5 |
| e-ISSN | 2234344X |
| Language | English |
| Publisher | The Korean Society for Applied Biological Chemistry |
| Publisher Date | 2014-09-26 |
| Publisher Place | Seoul |
| Access Restriction | Subscribed |
| Subject Keyword | vaccine CpG-oligodeoxynucleotide Applied Microbiology Biological Techniques epitope respiratory syncytial virus Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry, Genetics and Molecular Biology |
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