NDLI: Differential radiation sensitivity of shikonin derivatives from Lithospermum erythrorhizon S.

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Differential radiation sensitivity of shikonin derivatives from Lithospermum erythrorhizon S.

Content Provider	Springer Nature Link
Author	Moon, Yu Ran Cho, Jae Young Chung, Byung Yeoup Kim, Jin Hong Lee, Kang Soo Lee, Min Hee Lee, In Chul
Copyright Year	2003
Abstract	Differences in radiation sensitivity and color degradation of shikonin derivatives between the extracts of Lithospermum erythrorhizon root and authentic compounds were investigated. The degradation of shikonin derivatives in both root extracts and authentic compounds were drastically increased to above 8 kGy. HPLC analysis revealed radiation sensitivities of root extracts and authentic compounds differed significantly. Both shikonin and deoxyshikonin were the most sensitive with a degradation rate of 87–91%, while other derivatives in the extracts were the most resistant with a rate of 44–67%. Mixture of shikonin and deoxyshikonin showed a degradation rate of 20–24% at 4 kGy and around 60% at 8 kGy, whereas other shikonin derivatives showed a 48–62% degradation rate at 4 kGy and an 89–94% degradation at 8 kGy. The degradation pattern of shikonin derivatives in the mixture exhibited a similar pattern to those of the extract, but showed opposite pattern in individual derivative. The order of radiation sensitivity of shikonin derivatives are as follows: shikonin, deoxyshikonin>acetylshikonin, dimethylacrylshikonin, isobutyrylshikonin, isovalerylshikonin, 2-methyl-n-butyrylshikonin>hydroxyisovalerylshikonin in authentic compounds and isobutyrylshikonin, acetylshikonin, hydroxyisovalerylshikonin, isovalerylshikonin, 2-methyl-n-butyrylshikonin>deoxyshikonin, dimethylacrylshikonin>shikonin in root extracts.
Starting Page	724
Ending Page	728
Page Count	5
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	53
Issue Number	6
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	radiation sensitivity Applied Microbiology Biological Techniques gamma-ray Lithospermum erythrorhizon S. Bioorganic Chemistry shikonin
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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