NDLI: Antimicrobial and docking studies of (−)-catechin derivatives

Content Provider	Springer Nature Link
Author	Shin, Dong Soo Ganesh Kumar, C. Kumar, Deepak Kushwaha, R. N. Won, Tae Jin Jang, Kiwan Poornima, M. Ahn, Chuljin
Copyright Year	2015
Abstract	Antimicrobial activities of (−)-catechin derivatives were assayed for their antibacterial and antifungal activities against gram positive, gram negative bacteria, and fungi. Most of the compounds significantly active among which Compounds 1a, 1b, and 1c showed excellent antibacterial for both gram negative and gram positive bacteria, these compounds also exhibited excellent antifungal activity more than the standard drug. Molecular docking studies of Compounds 1a and 1b established good binding affinity with ATP-binding pocket of DNA gyrase and are in favor of the observed biological activity. These data collectively suggest that Compounds 1a and 1b could serve as a novel antimicrobial agent.
Starting Page	581
Ending Page	585
Page Count	5
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	58
Issue Number	4
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2015-05-16
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	Antifungal activities Neomycin (−)-catechin Applied Microbiology Biological Techniques Antibacterial activities Miconazole Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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Antimicrobial and docking studies of (−)-catechin derivatives