NDLI: The effects of Baekho-tang on 1-Fluoro-2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice

Content Provider	Springer Nature Link
Author	Lee, In Seung Ahn, Hyun Jin Kim, Kang Hoon Park, Jiyoung Kim, Yumi Han, Jin Woo Kim, Dong Hyun Jung, Ji Hoon Jung, Hee Jae Jang, Hyeung Jin
Copyright Year	2016
Abstract	Allergic contact dermatitis (ACD) is a cutaneous inflammatory response that is characterized skin lesion, increased cytokines secretion and splenomegaly. Baekho-tang (BHT) has been clinically used for the treatment of heat-related illnesses in Korea. Recently, it was reported that has an effect on epidemics such as hepatitis B, pneumonia, epidemic cerebrospinal meningitis and Japanese encephalitis. However, the effects of BHT on ACD is not yet fully studied. Therefore, the aims of this study was to determine the anti-allergic effects of BHT on 2, 4-dinitrofluorobenzene (DNFB)-induced ACD mice by investigating histopathologic examination of DNFB-induced inflamed tissues. Also, cytokines secretion in serum was determined using multiplex assay. The topical repeated application of DNFB on the dorsal skin of BALB/c mice were manifested the typical ACD. Treatment of different dose of BHT (20 or 80 mg/kg) attenuated DNFB-induced inflamed tissues such as erythema and crust. In addition, there is a trend for decreased serum cytokines levels in the treatment of high dose of BHT. Our results recommend that the high dose of BHT enhances the DNFB-induced ACD in mice.
Starting Page	349
Ending Page	354
Page Count	6
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	16
Issue Number	4
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-12-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Baekho-tang Anti-allergic effect Allergic contact dermatitis 1-Fluoro-2, 4-dinitrobenzene DNFB Biomedicine Pharmacy
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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