NDLI: Overexpression of keratin 17 is associated with poor prognosis in epithelial ovarian cancer

Content Provider	Springer Nature Link
Author	Wang, Ya Feng Lang, Hai Yang Yuan, Jing Wang, Jun Wang, Rui Zhang, Xin Hui Zhang, Jie Zhao, Tao Li, Yu Rong Liu, Jun Ye Zeng, Li Hua Guo, Guo Zhen
Copyright Year	2013
Abstract	The aim of this study was to investigate the association between keratin 17 (K17) expression and the clinicopathological features of patients with epithelial ovarian cancer (EOC). K17 expression was detected by real-time quantitative RT-PCR in EOC and adjacent noncancerous tissues. In addition, K17 expression was analyzed by immunohistochemistry in 104 clinicopathologically characterized EOC cases. The expression levels of K17 mRNA and protein in EOC tissues were both significantly higher than those in noncancerous tissues. In addition, positive expression of K17 correlated with the clinical stage (p = 0.001). Furthermore, Kaplan–Meier survival analysis showed that a high expression level of K17 resulted in a significantly poor prognosis of EOC patients. Multivariate analysis revealed that EOC expression level was an independent prognostic parameter for the overall survival rate of EOC patients. Our data are the first to suggest that increased K17 expression in EOC is significantly associated with aggressive progression and poor prognosis. K17 may be an important molecular marker for predicting the carcinogenesis, progression, and prognosis of EOC.
Starting Page	1685
Ending Page	1689
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-02-21
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	K17 EOC Biomarker Prognosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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