NDLI: Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis

Content Provider	Springer Nature Link
Author	Zhao, Ze Kun Wu, Wen Guang Chen, Lei Dong, Ping Gu, Jun Mu, Jia Sheng Yang, Jia Hua Liu, Ying Bin
Copyright Year	2013
Abstract	The aim of this current study was to investigate the clinicopathologic features and prognostic significance of UbcH10 in pancreatic ductal adenocarcinoma (PDA). Real-time quantitative RT-PCR was employed to examine UbcH10 expression in 20 pairs of PDA and adjacent non-cancerous tissues. In addition, UbcH10 expression was analyzed by immunohistochemistry in 94 clinicopathologically characterized PDA cases. The correlation of UbcH10 expression with patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Our results showed that the expression levels of UbcH10 mRNA and protein in PDA tissues were both significantly higher than those in non-cancerous tissues. Simultaneously, high expression of UbcH10 was significantly correlated with the clinical stage (p < 0.001), degree of histological differentiation (p < 0.001), and lymph node metastasis (p = 0.001). Moreover, high expression of UbcH10 was significantly associated with poor overall survival in PDA patients. In conclusion, UbcH10 might play a positive role in tumor development and could serve as an independent predictor of poor prognosis for PDA.
Starting Page	1473
Ending Page	1477
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-01-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	UbcH10 PDA Biomarker Prognosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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