NDLI: The association between cyclooxygenase-2 1195 G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis

Content Provider	Springer Nature Link
Author	Bu, Xianmin Zhao, Chenghai
Copyright Year	2013
Abstract	Cyclooxygenase-2 (COX-2) is proven to influence the carcinogenesis through immune response suppression, apoptosis inhibition, angiogenesis regulation, and tumor cell invasion. Previous studies assessing the association between COX-2 1195 G/A polymorphism and susceptibility to hepatocellular carcinoma (HCC) reported conflicting results. The objective of the study was to investigate the association between COX-2 1195 G/A polymorphism and HCC by a meta-analysis. PubMed, Embase, Web of Science, and Wangfang databases were searched for studies investigating the association between COX-2 1195 G/A polymorphism and HCC risk. The pooled odds ratio (OR) and its 95 % confidence interval (CI) were used to assess the strength of the association. Five studies with a total of 1,690 HCC cases and 1,961 controls were identified. Meta-analyses of total included studies showed that there was an obvious association between COX-2 1195 G/A polymorphism and HCC risk under two main genetic models (for AA versus GG, fixed-effects OR = 1.45, 95 % CI 1.15–1.81, P = 0.001, I $^{2}$ = 0.0 %; for AA/GA versus GG, fixed-effects OR = 1.26, 95 % CI 1.05–1.51, P = 0.011, I $^{2}$ = 0.0 %). Subgroup analysis by ethnicity showed that association was still obvious in Asians under two genetic models (for AA versus GG, fixed-effects OR = 1.45, 95 % CI 1.16–1.82, P = 0.001, I $^{2}$ = 21.7 %; for AA/GA versus GG, fixed-effects OR = 1.27, 95 % CI 1.05–1.54, P = 0.013, I $^{2}$ = 0.4 %). The evidence from the meta-analysis supports an association between COX-2 1195 G/A polymorphism and HCC risk in Asians. Further studies with large sample and careful design are needed to identify the possible association in Caucasians.
Starting Page	1479
Ending Page	1484
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	COX-2 Single-nucleotide polymorphism Hepatocellular carcinoma Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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