NDLI: CXCR4-mediated Stat3 activation is essential for CXCL12-induced cell invasion in bladder cancer

Content Provider	Springer Nature Link
Author	Shen, Hai bo Gu, Zheng qin Jian, Kang Qi, Juan
Copyright Year	2013
Abstract	CXCL12/CXCR4 signaling plays important roles in tumor cell metastasis in many types of cancers, and CXCR4 is the key regulator of cell motility in bladder cancer. Emerging evidence suggests that transcription-3 (Stat3) activation is associated with bladder cancer cell growth and survival, while the relationship between CXCL12/CXCR4 signal and Stat3 activation remains unclear. In this study, expression analysis of bladder cancer and adjacent normal tissues showed that higher CXCR4 expression was associated with Stat3 phosphorylation. CXCR4 knockdown in bladder cancer T24 cells impaired CXCL12-induced cell invasion and Stat3 activation. Furthermore, blocking Stat3 activity with the chemical inhibitor Stattic inhibited CXCL12-triggered Stat3 phosphorylation and cell invasion in T24 cells, suggesting that Stat3 activation is required for CXCL12 function in the mobility of bladder cancer. Taken together, CXCR4 is necessary for CXCL12 signal transduction in bladder cancer, and CXCL12/CXCR4 promotes invasion of bladder cancer cells through activation of Stat3 transcriptional activity.
Starting Page	1839
Ending Page	1845
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-23
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	CXCL12 CXCR4 Stat3 Cell invasion Bladder cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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