NDLI: Glutathione S-transferase T1 null genotype and laryngeal cancer risk: a meta-analysis

Content Provider	Springer Nature Link
Author	Li, Qiuying Liu, Ming
Copyright Year	2014
Abstract	Glutathione S-transferase T1 (GSTT1) polymorphic variation has been implicated as a risk factor for various cancers. However, previous studies investigating the association between GSTT1 null genotype and laryngeal cancer risk in Asians reported conflicting outcomes. In the present study, the possible association of laryngeal cancer risk with GSTT1 null genotype was explored by a meta-analysis. Relevant studies were identified through a systemic search of PubMed and Chinese National Knowledge Infrastructure databases. Six studies with a total of 1,824 individuals were included in the meta-analysis. The pooled odds ratio (OR) with 95 % confidence interval (CI) was used to assess the association. Meta-analysis of all included studies showed that there was an obvious association between GSTT1 null genotype and laryngeal cancer risk in Asians (OR = 2.41, 95 % CI 1.27–4.57, P = 0.007, I $^{2}$ = 86 %). After adjusting for heterogeneity, there was still an obvious association between GSTT1 null genotype and laryngeal cancer risk in Asians (OR = 1.75, 95 % CI 1.36–2.24, P < 0.001, I $^{2}$ = 0 %). The findings from the meta-analysis suggest that GSTT1 null genotype is associated with laryngeal cancer risk in Asians.
Starting Page	8781
Ending Page	8785
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-05-31
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Laryngeal cancer Glutathione S-transferase T1 Association Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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