NDLI: Role of IL-17F T7488C polymorphism in carcinogenesis: a meta-analysis

Content Provider	Springer Nature Link
Author	Yao, Fen Yan, Shushan Wang, Xiaochen Shi, Denghui Bai, Jianye Li, Feng Sun, Beicheng Qian, Bin
Copyright Year	2014
Abstract	Previous case-control studies on the association of interleukin-17F (IL-17F) T7488C polymorphism and cancer risk have yielded conflicting and inconclusive findings. We performed a meta-analysis by pooling all currently available data to acquire a more precise estimation of the association. A comprehensive literature screening from the PubMed, Embase, Web of Science, and Wanfang databases was performed for eligible publications without language restrictions. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (95 % CIs) were calculated. According to the inclusion criteria, a total of nine case-control studies with 3,034 cases and 3,694 controls were included. Overall, the pooled ORs showed that IL-17F T7488C polymorphism was associated with neither increased nor decreased risk of cancer. However, the IL-17F T7488C polymorphism exerted risk effect on cancer in population-based case-control studies when stratifying analysis by source of controls (C vs T OR = 1.24, 95 % CI, 1.10–1.40, pooled OR (P$_{OR}$) < 0.001; TC vs TT OR = 1.28, 95 % CI, 1.11–1.48, P$_{OR}$ = 0.001; CC + TC vs TT OR = 1.29, 95 % CI, 1.12–1.48, P$_{OR}$ < 0.001). Additionally, the variant genotypes of IL-17F T7488C could alter the risk of gastric cancer under the following comparisons (C vs T OR = 1.29, 95 % CI, 1.13–1.47, P$_{OR}$ < 0.001; TC vs TT OR = 1.35, 95 % CI, 1.14–1.60, P$_{OR}$ < 0.001; CC + TC vs TT OR = 1.35, 95 % CI, 1.15–1.58, P$_{OR}$ < 0.001). Sensitivity analysis by sequential omission of single study did not materially alter the pooled findings. The present meta-analysis suggests that the IL-17F T7488C polymorphism may modify the risk of cancer, particularly gastric cancer. However, the precise association needs to be elucidated by more individual studies with sufficient statistical power.
Starting Page	9061
Ending Page	9068
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-10
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Interleukin-17F Polymorphism Cancer Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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