NDLI: Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population

Content Provider	Springer Nature Link
Author	Che, Jianhua Jiang, Dong Zheng, Yabiao Zhu, Bin Zhang, Ping Lu, Deyi Zhang, Junjie Xiao, Juanjuan Wang, Jianguo Gao, Yuzhen Yan, Xiaolong Wang, Minghua
Copyright Year	2014
Abstract	Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis. The prolyl hydrolase 1 (PHD1) is a key adjustment factor that mediates the HIF-1 degradation and relates with the process of tumorigenesis. Thus, polymorphism in PHD1 may affect cellular response to hypoxic conditions and associate with cancer susceptibility. We conducted a case–control study with 406 non-small cell lung cancer cases and 812 healthy controls matched on age and sex to examine the effect of rs10680577 polymorphism within the PHD1 promoter on non-small cell lung cancer (NSCLC) risk in a Chinese population. The genotype of rs10680577 polymorphism was detected by non-denaturing polyacrylamide gel electrophoresis. The ins/del genotype of rs10680577 was associated with significantly increased non-small cell lung cancer risk (ins/del vs. ins/ins: OR = 1.35, 95 % confidence interval (CI) 1.05–1.74, P = 0.020; ins/del vs. ins/ins + del/del: OR = 1.34, 95 % CI = 1.04–1.72, P = 0.022). In addition, the association was more pronounced in the group of >60 years of age. rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population. This is the first time to show that PHD1 rs10680577 is associated NSCLC risk.
Starting Page	8921
Ending Page	8925
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-04
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	PHD1 rs10680577 Non-small cell lung cancer Polymorphism Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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