NDLI: Multiple roles of CD90 in cancer

Content Provider	Springer Nature Link
Author	Kumar, Atul Bhanja, Anshuman Bhattacharyya, Jina Jaganathan, Bithiah Grace
Copyright Year	2016
Abstract	THY1 (CD90) is a 25–37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal stem cells, hematopoietic stem cells, natural killer cells, neurons, endothelial cells, renal glomerular mesangial cells, follicular dendritic cells, fibroblasts, and myofibroblasts. It has been found to regulate cell adhesion, migration, apoptosis, axon growth, cell-cell and cell-matrix interactions, T-cell activation, and fibrosis. Several reports have shown that CD90 has an important role in cancer in regulating cancer cell proliferation, metastasis, and angiogenesis. There are also evidences that CD90 is an important prognostic marker in many cancers. Consequently, therapies that target CD90 have great promise in treating many cancers. However, several studies also indicate a contradictory role for CD90, where it acts as a tumor suppressor. In this review, we summarize the expression, function of CD90 in different cancers and its possible use as a biomarker or a therapeutic target in cancer. The challenges and future prospects for the use of CD90 for clinical applications are also discussed in this review.
Starting Page	11611
Ending Page	11622
Page Count	12
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-06-23
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	CD90 Cancer Metastasis Stem cells Microenvironment Biomarker Prognosis Therapy Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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