NDLI: Targeted nanobubbles in low-frequency ultrasound-mediated gene transfection and growth inhibition of hepatocellular carcinoma cells

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Tumor Biology : Volume 37

Tumor Biology : Volume 37, Issue 12, December 2016

Tumor Biology : Volume 37, Issue 11, November 2016

Tumor Biology : Volume 37, Issue 10, October 2016

Tumor Biology : Volume 37, Issue 9, September 2016

Complex roles of NRAGE on tumor

MTOR inhibitors in urinary bladder cancer

Role of interleukin-6 in cancer progression and therapeutic resistance

Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs—syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin’s lymphoma

Emerging targets for radioprotection and radiosensitization in radiotherapy

Multiple roles of CD90 in cancer

Role of long non-coding RNA in tumor drug resistance

Noninvasive detection of gastric cancer

Potential biomarkers for anti-EGFR therapy in metastatic colorectal cancer

The choice of endogenous controls in exosomal microRNA assessments from biofluids

The dual regulatory role of miR-204 in cancer

Mesenchymal stem cells as a double-edged sword in suppression or progression of solid tumor cells

Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

Functional and clinical significance of SALL4 in breast cancer

The insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies

Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression

The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma

Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo

Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis

GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular carcinoma

Efficient isolation and proteomic analysis of cell plasma membrane proteins in gastric cancer reveal a novel differentiation and progression related cell surface marker, R-cadherin

Wnt-11 overexpression promoting the invasion of cervical cancer cells

The roles of serum PDCD5 in circulating CD133 positive cells of the patients with gastric cancer

25-methoxyl-dammarane-3β, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation through downregulation of testes-specific protease 50 (TSP50) expression

High miR-96 levels in colorectal adenocarcinoma predict poor prognosis, particularly in patients without distant metastasis at the time of initial diagnosis

Impact of X-linked inhibitor of apoptosis protein on survival of nasopharyngeal carcinoma patients following radiotherapy

Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models

Evidence for embryonic stem-like signature and epithelial-mesenchymal transition features in the spheroid cells derived from lung adenocarcinoma

Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue

Time courses and value of circulating microparticles in patients with operable stage non-small cell lung cancer undergoing surgical intervention

Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling activation

Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion

The value of plasma netrin-1 in non-small cell lung cancer patients as diagnostic and prognostic biomarker

Circulating levels of TNF-related apoptosis inducing-ligand are decreased in patients with large adult-type granulosa cell tumors—implications for therapeutic potential

Shorter telomeres and high telomerase activity correlate with a highly aggressive phenotype in breast cancer cell lines

Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer

A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia

EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway

A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells

Analysis of APOBEC3A/3B germline deletion polymorphism in breast, cervical and oral cancers from South India and its impact on miRNA regulation

Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry

Genetic analysis of radiation-specific biomarkers in sinonasal squamous cell carcinomas

Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer

MiR-96 promotes the growth of prostate carcinoma cells by suppressing MTSS1

Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncology

TUSC3 suppresses glioblastoma development by inhibiting Akt signaling

DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition

MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer

The clinical significance of changes in ezrin expression in osteosarcoma of children and young adults

Usefulness of the preoperative platelet count in the diagnosis of adnexal tumors

Poly (I:C) enhances the anti-tumor activity of canine parvovirus NS1 protein by inducing a potent anti-tumor immune response

Genetic polymorphism of HLA-DQ confers susceptibility to hepatitis B virus-related hepatocellular carcinoma: a case-control study in Han population in China

Targeted nanobubbles in low-frequency ultrasound-mediated gene transfection and growth inhibition of hepatocellular carcinoma cells

Evaluation of $^{68}$Ga-labeled iNGR peptide with tumor-penetrating motif for microPET imaging of CD13-positive tumor xenografts

Expression and clinical significance of Wee1 in colorectal cancer

MicroRNA-125b promotes invasion and metastasis of gastric cancer by targeting STARD13 and NEU1

SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway

MiR-21 modulates radiosensitivity of cervical cancer through inhibiting autophagy via the PTEN/Akt/HIF-1α feedback loop and the Akt-mTOR signaling pathway

Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression

TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells

DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway

Feedback mechanisms between M2 macrophages and Th17 cells in colorectal cancer patients

Overexpression of miR-203 sensitizes paclitaxel (Taxol)-resistant colorectal cancer cells through targeting the salt-inducible kinase 2 (SIK2)

S100A16 promotes cell proliferation and metastasis via AKT and ERK cell signaling pathways in human prostate cancer

Gene expression profile analysis in response to α1,2-fucosyl transferase (FUT1) gene transfection in epithelial ovarian carcinoma cells

Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase

Serum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection

High alpha-methylacyl-CoA racemase (AMACR) is associated with ERG expression and with adverse clinical outcome in patients with localized prostate cancer

Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer

Integrinβ1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas

Germline mutations of BRCA1 gene exon 11 are not associated with platinum response neither with survival advantage in patients with primary ovarian cancer: understanding the clinical importance of one of the biggest human exons. A study of the Tumor Bank Ovarian Cancer (TOC) Consortium

The clinicopathological significance of miR-149 and PARP-2 in hepatocellular carcinoma and their roles in chemo/radiotherapy

Synergistic increase in efficacy of a combination of 2-deoxy-d-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis

Laminin-adherent versus suspension-non-adherent cell culture conditions for the isolation of cancer stem cells in the DAOY medulloblastoma cell line

Osteopontin expression in co-cultures of human squamous cell carcinoma-derived cells and osteoblastic cells and its effects on the neoplastic cell phenotype and osteoclastic activation

HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation

TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer

Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3β signaling in gastric cancer

EphA4-mediated signaling regulates the aggressive phenotype of irradiation survivor colorectal cancer cells

Comparison of cell cycle components, apoptosis and cytoskeleton-related molecules and therapeutic effects of flavopiridol and geldanamycin on the mouse fibroblast, lung cancer and embryonic stem cells

Secretome of tumor-associated leukocytes augment epithelial-mesenchymal transition in positive lymph node breast cancer patients via activation of EGFR/Tyr845 and NF-κB/p65 signaling pathway

Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells

Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps

Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation

IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes

The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2

INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia

The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer

Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin

In silico designing, cloning, and heterologous expression of novel chimeric human B lymphocyte CD20 extra loop

Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues

GPC-HCC model: a combination of glybican-3 with other routine parameters improves the diagnostic efficacy in hepatocellular carcinoma

Cytotoxicity of withasteroids: withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells

Low absolute CD4$^{+}$ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma

Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma

Aberrant DNA methylation of acute myeloid leukemia and colorectal cancer in a Chinese pedigree with a MLL3 germline mutation

A novel index for preoperative, non-invasive prediction of macro-radical primary surgery in patients with stage IIIC–IV ovarian cancer—a part of the Danish prospective pelvic mass study

Expression profiles of miR-29c, miR-200b and miR-375 in tumour and tumour-adjacent tissues of head and neck cancers

Galectin-8 is associated with recurrence and survival of patients with non-metastatic gastric cancer after surgery

Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment

P16 upregulation is linked to poor prognosis in ERG negative prostate cancer

ZNRF3 is downregulated in papillary thyroid carcinoma and suppresses the proliferation and invasion of papillary thyroid cancer cells

Profiling of mRNA and long non-coding RNA of urothelial cancer in recipients after renal transplantation

MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer

The alpha-fetoprotein (AFP) third domain: a search for AFP interaction sites of cell cycle proteins

4.1N is involved in a flotillin-1/β-catenin/Wnt pathway and suppresses cell proliferation and migration in non-small cell lung cancer cell lines

Silencing of TGIF attenuates the tumorigenicity of A549 cells in vitro and in vivo

CYLD downregulates Livin and synergistically improves gemcitabine chemosensitivity and decreases migratory/invasive potential in bladder cancer: the effect is autophagy-associated

From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis

Meta-analysis of gene expression profiles identifies differential biomarkers for hepatocellular carcinoma and cholangiocarcinoma

PIK3CD promoted proliferation in diffuse large B cell lymphoma through upregulation of c-myc

HIC1 modulates uveal melanoma progression by activating lncRNA-numb

Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis

Overexpression of p42.3 promotes cell proliferation, migration, and invasion in human gastric cancer cells

ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway

The expression of Cullin1 is increased in renal cell carcinoma and promotes cancer cell proliferation, migration, and invasion

Primary cultures of human colon cancer as a model to study cancer stem cells

Loss of miR-26a-5p promotes proliferation, migration, and invasion in prostate cancer through negatively regulating SERBP1

Overexpression of MYCN promotes proliferation of non-small cell lung cancer

Overexpression of LncRNA-ROR predicts a poor outcome in gallbladder cancer patients and promotes the tumor cells proliferation, migration, and invasion

Construction of random tumor transcriptome expression library for creating and selecting novel tumor antigens

ABCG2 is required for self-renewal and chemoresistance of CD133-positive human colorectal cancer cells

Note of the methodological flaws in the paper entitled “GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis”

Erratum to: Spheroid-plug model as a tool to study tumor development, angiogenesis, and heterogeneity in vivo

Erratum to: Neutrophil-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma

Tumor Biology : Volume 37, Issue 1, Supplement,September 2016

Tumor Biology : Volume 37, Issue 8, August 2016

Tumor Biology : Volume 37, Issue 7, July 2016

Tumor Biology : Volume 37, Issue 6, June 2016

Tumor Biology : Volume 37, Issue 5, May 2016

Tumor Biology : Volume 37, Issue 4, April 2016

Tumor Biology : Volume 37, Issue 3, March 2016

Tumor Biology : Volume 37, Issue 2, February 2016

Tumor Biology : Volume 37, Issue 1, January 2016

Tumor Biology : Volume 36

Tumor Biology : Volume 35

Tumor Biology : Volume 34

Tumor Biology : Volume 33

Tumor Biology : Volume 32

Tumor Biology : Volume 31

Targeted nanobubbles in low-frequency ultrasound-mediated gene transfection and growth inhibition of hepatocellular carcinoma cells

Content Provider	Springer Nature Link
Author	Wu, Bolin Qiao, Qiang Han, Xue Jing, Hui Zhang, Hao Liang, Hongjian Cheng, Wen
Copyright Year	2016
Abstract	The use of SonoVue combined with ultrasound exposure increases the transfection efficiency of short interfering RNA (siRNA). The objective of this study was to prepare targeted nanobubbles (TNB) conjugated with NET-1 siRNA and an antibody GPC3 to direct nanobubbles to hepatocellular carcinoma cells. SMMC-7721 human hepatocellular carcinoma cells were treated with six different groups. The transfection efficiency and cellular apoptosis were measured by flow cytometry. The protein and messenger RNA (mRNA) expression were measured by Western blot and quantitative real-time PCR, respectively. The migration and invasion potential of the cells were determined by Transwell analysis. The results show that US-guided siRNA-TNB transfection effectively enhanced gene silencing. In summary, siRNA-TNB may be an effective delivery vector to mediate highly effective RNA interference in tumor treatment.
Starting Page	12113
Ending Page	12121
Page Count	9
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-05-23
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Hepatocellular carcinoma siRNA Nanobubbles Ultrasound Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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