NDLI: Role of Lgr5-positive cells in colorectal cancer

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Tumor Biology : Volume 37

Tumor Biology : Volume 36

Tumor Biology : Volume 36, Issue 12, December 2015

Tumor Biology : Volume 36, Issue 11, November 2015

Tumor Biology : Volume 36, Issue 10, October 2015

Tumor Biology : Volume 36, Issue 9, September 2015

Current position of TNF-α in melanomagenesis

Endothelial progenitor cells support tumour growth and metastatisation: implications for the resistance to anti-angiogenic therapy

Malignant tumors of the uterine corpus: molecular background of their origin

Survivin splice variants and their diagnostic significance

Genetic susceptibility to cervical cancer: role of common polymorphisms in apoptosis-related genes

MicroRNA-224: as a potential target for miR-based therapy of cancer

Breast cancer circulating biomarkers: advantages, drawbacks, and new insights

Question about Liu Y et al. entitled “Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies”

Reply to: “in vivo post-contrast 1H-MRS evaluation of malignant and benign breast lesions: a meta-analysis”

Letter regarding Zhang et al. entitled “Systematic review of high-dose and standard-dose chemotherapies in the treatment of primary well-differentiated osteosarcoma”

AdipoRon: a possible drug for colorectal cancer prevention?

RETRACTED ARTICLE: Risperidone promotes differentiation of glioma stem-like cells through the Wnt signaling pathway

Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma

Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2

Interaction with CCNH/CDK7 facilitates CtBP2 promoting esophageal squamous cell carcinoma (ESCC) metastasis via upregulating epithelial-mesenchymal transition (EMT) progression

MicroRNA-1 (miR-1) inhibits gastric cancer cell proliferation and migration by targeting MET

MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK

Decreased expression of RPS15A suppresses proliferation of lung cancer cells

MiR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM

Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer

Role of Lgr5-positive cells in colorectal cancer

Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cells

Lifetime effectiveness of mifamurtide addition to chemotherapy in nonmetastatic and metastatic osteosarcoma: a Markov process model analysis

A polysaccharide from the alkaline extract of Glycyrrhiza inflata induces apoptosis of human oral cancer SCC-25 cells via mitochondrial pathway

Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13

Prognostic significance of SLC9A9 in patients with resectable esophageal squamous cell carcinoma

MiR-30 overexpression promotes glioma stem cells by regulating Jak/STAT3 signaling pathway

ObRb downregulation increases breast cancer cell sensitivity to tamoxifen

MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1

Clinical significance of topoisomerase 2A expression and gene change in operable invasive breast cancer

Antitumor activity of photodynamic therapy with a chlorin derivative in vitro and in vivo

Clinical significance and biological roles of TRIM24 in human bladder carcinoma

The M30 assay does not detect apoptosis in epithelial-derived cancer cells expressing low levels of cytokeratin 18

MicroRNA-9 promotes tumorigenesis and mediates sensitivity to cisplatin in primary epithelial ovarian cancer cells

MiR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W

Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT

Influence of CCND1 G870A polymorphism on the risk of HBV-related HCC and cyclin D1 splicing variant expression in Chinese population

Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma

Mdig, a lung cancer-associated gene, regulates cell cycle progression through p27$^{KIP1}$

Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women

MicroRNA-199a-3p suppresses glioma cell proliferation by regulating the AKT/mTOR signaling pathway

Clinical pathological characteristics of breast cancer patients with secondary diabetes after systemic therapy: a retrospective multicenter study

MicroRNA-144 inhibits the proliferation, apoptosis, invasion, and migration of osteosarcoma cell line F5M2

Gender and plasma iron biomarkers, but not HFE gene mutations, increase the risk of colorectal cancer and polyps

Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer

Interference with the β-catenin gene in gastric cancer induces changes to the miRNA expression profile

MicroRNA signatures in total peripheral blood of gallbladder cancer patients

Involvement of multiple cellular pathways in regulating resistance to tamoxifen in BIK-suppressed MCF-7 cells

Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma

MiR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma

A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway

C-reactive protein inhibits expression of N-cadherin and ZEB-1 in murine colon adenocarcinoma

ALDH1 might influence the metastatic capability of HeLa cells

Coexpression of c-Met and Notch-1 correlates with poor prognosis in resected non-small-cell lung cancer

The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue

Prognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients

The role of hypoxia-inducible factor-1α in radiation-induced autophagic cell death in breast cancer cells

A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo

The role of H. pylori infection in gall bladder cancer: clinicopathological study

Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma

Demethoxycurcumin was prior to temozolomide on inhibiting proliferation and induced apoptosis of glioblastoma stem cells

Antineoplastic activity of Newcastle disease virus strain D90 in oral squamous cell carcinoma

JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression

RETRACTED ARTICLE: MiRNA-494 inhibits metastasis of cervical cancer through Pttg1

Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients

Overexpression of YB1 and EZH2 are associated with cancer metastasis and poor prognosis in renal cell carcinomas

Plasma microRNA might as a potential biomarker for hepatocellular carcinoma and chronic liver disease screening

Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer

The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer

Overexpression of stathmin is resistant to paclitaxel treatment in patients with non-small cell lung cancer

Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma

Akt2/ZEB2 may be a biomarker for exfoliant cells in ascitic fluid in advanced grades of serous ovarian carcinoma

K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation

A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer

ShRNA-mediated knock-down of CXCR7 increases TRAIL-sensitivity in MCF-7 breast cancer cells

RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model

Expression of FOXP1 in epithelial ovarian cancer (EOC) and its correlation with chemotherapy resistance and prognosis

RETRACTED ARTICLE: MiR-34a suppresses ovarian cancer proliferation and motility by targeting AXL

VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density

Retraction Note to: A translocator protein ligand PK11195 shows antigrowth activity in human choriocarcinoma cells

Retraction Note to: Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells

Retraction Note to: Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells

Retraction Note to: Comparison of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and combined HCC-CC (CHC) with each other based on microarray dataset

Retraction Note to: Silencing of the Smad nuclear interacting protein 1 (SNIP1) by siRNA inhibits proliferation and induces apoptosis in pituitary adenoma cells

Retraction Note to: Promoter methylation of DAPK gene may contribute to the pathogenesis of nonsmall cell lung cancer: a meta-analysis

Retraction Note to: Relationship between VEGF protein expression and lymph node metastasis in papillary thyroid carcinoma among Asians: a meta-analysis

Retraction Note to: Correlations of IFN-γ genetic polymorphisms with susceptibility to breast cancer: a meta-analysis

Retraction Note to: relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis

Retraction Note to: Relationships between genetic polymorphisms in inflammation-related factor gene and the pathogenesis of nasopharyngeal cancer

Retraction Note to: Single-nucleotide polymorphisms of LIG1 associated with risk of lung cancer

Retraction Note to: Aberrant promoter methylation of the CHD1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis

Retraction Note to: Prognostic value of CD133 expression in cancer patients treated with chemoradiotherapy: a meta-analysis

Retraction Note to: Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population

Retraction Note to: Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis

Retraction Note to: Relationship of serum MMP-7 levels for colorectal cancer: a meta-analysis

Retraction Note to: Correlation of IL-1F genetic polymorphisms with the risk of colorectal cancer among Chinese populations

Retraction Note to: A comprehensive analysis of candidate genes and pathways in pancreatic cancer

Retraction Note to: Identification of core miRNA based on small RNA-seq and RNA-seq for colorectal cancer by bioinformatics

Erratum to: Thioridazine specifically sensitizes drug-resistant cancer cells through highly increase in apoptosis and P-gp inhibition

Erratum to: Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer

Tumor Biology : Volume 36, Issue 1, Supplement,September 2015

Tumor Biology : Volume 36, Issue 8, August 2015

Tumor Biology : Volume 36, Issue 7, July 2015

Tumor Biology : Volume 36, Issue 6, June 2015

Tumor Biology : Volume 36, Issue 5, May 2015

Tumor Biology : Volume 36, Issue 4, April 2015

Tumor Biology : Volume 36, Issue 3, March 2015

Tumor Biology : Volume 36, Issue 2, February 2015

Tumor Biology : Volume 36, Issue 1, January 2015

Tumor Biology : Volume 35

Tumor Biology : Volume 34

Tumor Biology : Volume 33

Tumor Biology : Volume 32

Tumor Biology : Volume 31

Role of Lgr5-positive cells in colorectal cancer

Content Provider	Springer Nature Link
Author	Ding, Honghua Wang, Chungang
Copyright Year	2015
Abstract	The molecular regulation of the growth of colorectal cancer (CRC) cells is not completely understood. Here, we report expression of Lgr5, a stem cell marker for the intestine and hair follicle, in some of the CRC cells in the patients. To determine the role of Lgr5-positive cells in the tumorigenesis of CRCs, we prepared an adeno-associated virus (AAV) that carries diphtheria toxin fragment A (DTA) under the control of Lgr5 promoter (AAV-pLgr5-DTA). Transduction of several CRC cell lines with this virus selectively killed Lgr5-positive cells, resulting in significant inhibition of the CRC cell growth in vitro and in vivo. Thus, our data highlight a potential role of Lgr5-positive cells in the tumorigenesis of CRCs, and suggest that treating these Lgr5-positive cells in CRCs may substantially improve the outcome of CRC therapy.
Starting Page	6759
Ending Page	6764
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-03
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lgr5 Colorectal cancer Diphtheria toxin fragment A (DTA) Tumorigenesis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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