NDLI: Demethoxycurcumin was prior to temozolomide on inhibiting proliferation and induced apoptosis of glioblastoma stem cells

Content Provider	Springer Nature Link
Author	Shi, Lei Fei, Xifeng Wang, Zhimin
Copyright Year	2015
Abstract	Temozolomide (TMZ) is widely used for treating glioblastoma (GBM), which can effectively inhibit the GBM growth for some months; however, it still could not prevent the invariable recurrence of GBM. The existence of glioma stem cells (GSCs) was considered to be a key factor. But TMZ has poor effects on GSCs. Recently, demethoxycurcumin (DMC) has been shown to display anti-tumor activities in malignant gliomas. However, its effects and the potential mechanisms on GSCs were still unclear. Our study showed that DMC was prior to TMZ on resulting in a significant increase in GSC apoptosis and a marked inhibition of cell growth in vitro. And combined treatment of DMC and TMZ showed more significant anti-GSC effects. Further research into the underlying mechanism demonstrated that this novel combinatorial regimen leads to changes of multiple cell signaling pathways including reactive oxygen species (ROS) production and caspase-3 signaling mitochondria-related apoptosis activation as well as inactivation of JAK/STAT3 signaling pathway. Taken together, our data demonstrate that the anti-GSC effects of DMC are better than TMZ, and combined treatment of DMC and TMZ has much stronger effects on GSCs.
Starting Page	7107
Ending Page	7119
Page Count	13
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	9
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-16
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Temozolomide Demethoxycurcumin Glioblastoma stem cell Proliferation Apoptosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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