NDLI: The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients

Content Provider	Springer Nature Link
Author	Li, Xiang Ping Yin, Ji Ye Wang, Ying He, Hui Li, Xi Gong, Wei Jing Chen, Juan Qian, Chen Yue Zheng, Yi Li, Fang Yin, Tao Gong, Zhi Cheng Zhou, Bo Ting Zhang, Yu Xiao, Ling Zhou, Hong Hao Liu, Zhao Qian
Copyright Year	2014
Abstract	This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total of 338 Chinese Han lung cancer patients were enrolled in this study. All patients underwent at least two cycles of platinum-based chemotherapy. Four tag SNPs of ATP7B (rs1061472, rs9535826, rs7999812, and rs9535828) were selected to evaluate their impacts to platinum-based chemotherapy in these patients. ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients. Patients with A allele in ATP7B rs9535828 presented an increased susceptibility to platinum drugs (OR 1.96, 95 % CI 1.17–3.30, p < 0.01). Patients with G allele in ATP7B rs9535826 had the highest susceptibility to platinum drugs (OR 2.05, 95 % CI 1.19–3.52, p < 0.01). Our findings suggest that ATP7B genetic polymorphisms could affect the therapeutic efficacy of platinum-based chemotherapy, and ATP7B gene might be considered as predictive markers for the efficacy evaluation of platinum-based chemotherapy in Chinese Han lung cancer patients.
Starting Page	8259
Ending Page	8265
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-05-23
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	ATP7B Polymorphism Lung cancer Platinum Chemotherapy Efficacy Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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