NDLI: Neurotoxic effects by silica TM nanoparticle is independent of differentiation of SH-SY5Y cells

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Molecular & Cellular Toxicology : Volume 7, Issue 3, September 2011

Molecular & Cellular Toxicology : Volume 7, Issue 2, June 2011

Molecular & Cellular Toxicology : Volume 7, Issue 1, March 2011

Molecular & Cellular Toxicology : Volume 6

Neurotoxic effects by silica TM nanoparticle is independent of differentiation of SH-SY5Y cells

Content Provider	Springer Nature Link
Author	Kim, Youn Jung Yang, Sung Ik
Copyright Year	2011
Abstract	Silica nanoparticles are being formulated for potential drug delivery and for imaging and diagnostic applications in the central nervous system (CNS). However, the potential and underlying mechanism of silica nanoparticles-mediated neurotoxicity has remained unclear. We examined the effect of colloidal silica nanoparticle (LUDOX® TM) on neurite outgrowth and neurotoxicity of human SH-SY5Y neuroblastoma cells differentiated by all-trans-retinoic acid (RA). Exposure of >300 ppm of SiO$_{2}$ TM nanoparticle in differentiating cells showed less cytotoxicity than in undifferentiated cells. 100 ppm of SiO$_{2}$ TM nanoparticle had no significant difference on the viability of either undifferentiated or differentiating SH-SY5Y cells. Neurite outgrowth in differentiating cells for 48 h exposure of 100 ppm SiO$_{2}$ TM nanoparticle was not significantly changed. Thus, SiO$_{2}$ TM nanoparticle appeared no effects in the early initiation of neurites. And also, although the production of reactive oxygen species (ROS) was not induced, neurotoxicity resulted by SiO$_{2}$ TM nanoparticle may be the result of increased DNA damage, apoptosis, and cell cycle arrest in undifferentiated and differentiating cells. Further studies are needed to investigate the expression of genes in these signaling pathways in response to exposure to silica nanoparticle and to investigate the molecular mechanisms of neuronal cell effects.
Starting Page	381
Ending Page	388
Page Count	8
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	7
Issue Number	4
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2012-01-04
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Silica nanoparticle Differentiation Neurotoxicity Apoptosis Comet assay Cell cycle arrest Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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