WebSite Logo
  • Content
  • Similar Resources
  • Metadata
  • Cite This
  • Log-in
  • Fullscreen
Log-in
Do not have an account? Register Now
Forgot your password? Account recovery
  1. Toxicology and Environmental Health Sciences
  2. Toxicology and Environmental Health Sciences : Volume 3
  3. Toxicology and Environmental Health Sciences : Volume 3, Issue 1, March 2011
  4. Genotoxicity of nano-silica in mammalian cell lines
Loading...

Please wait, while we are loading the content...

Toxicology and Environmental Health Sciences : Volume 9
Toxicology and Environmental Health Sciences : Volume 8
Toxicology and Environmental Health Sciences : Volume 7
Toxicology and Environmental Health Sciences : Volume 6
Toxicology and Environmental Health Sciences : Volume 5
Toxicology and Environmental Health Sciences : Volume 4
Toxicology and Environmental Health Sciences : Volume 3
Toxicology and Environmental Health Sciences : Volume 3, Issue 4, December 2011
Toxicology and Environmental Health Sciences : Volume 3, Issue 1, Supplement,October 2011
Toxicology and Environmental Health Sciences : Volume 3, Issue 3, September 2011
Toxicology and Environmental Health Sciences : Volume 3, Issue 2, June 2011
Toxicology and Environmental Health Sciences : Volume 3, Issue 1, March 2011
Growth inhibition of aquatic plant caused by silver and titanium oxide nanoparticles
Genotoxicity of nano-silica in mammalian cell lines
DNA repair capacity marks susceptibility in pediatric asthma patients following low levels of polycyclic aromatic hydrocarbon exposure
Unleaded gasoline use and lead level change in human blood
Gene expression analysis identifies potential biomarkers of phenanthrene in human hepatocytes (HepG2)
Identification of differentially expressed genes in liver of marine medaka fish exposed to benzo[a]pyrene
Status and trend of butyltin contamination in Masan Bay, Korea
The survey on use of photo-catalytic nanoparticles in Korea
Toxicology and Environmental Health Sciences : Volume 2
Toxicology and Environmental Health Sciences : Volume 1

Similar Documents

...
Cytotoxicity and genotoxicity of nano-silver in mammalian cell lines

Article

...
Comparative genotoxicity investigation using comet and gammaH2AX assays for screening of genotoxicants in HepG2 human hepatoma cells

Article

...
Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by silica nanomaterials in human neuronal cell line

Article

...
Assessment of DNA damage caused by locally produced hydroxyapatite-silica nanocomposite using Comet assay on human lung fibroblast cell line

Article

...
Neurotoxic effects by silica TM nanoparticle is independent of differentiation of SH-SY5Y cells

Article

...
Comet assay: an essential tool in toxicological research

Article

...
Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests.

Article

...
Toxicity assessment of a novel silk fibroin and poly-methyl-methacrylate composite material

Article

...
Synthesis of silica encapsulated DVB nano-particles for toxicology application

Article

Genotoxicity of nano-silica in mammalian cell lines

Content Provider Springer Nature Link
Author Choi, Han Saem Kim, Youn Jung Song, Mee Song, Mi Kyung Ryu, Jae Chun
Copyright Year 2011
Abstract Nanomaterials are defined by the U.S. National Nanotechnology Initiative as materials that have at least one dimension in the 1- to 100-nm range. Due to their unique physical and chemical characteristics, nanotechnology has become one of the leading technologies over the past 10 years. This study represents data on genotoxic effects of nanoparticles and their application for assessing human health risks. Silica (SiO$_{2}$) is a multi-functional ceramic material that is being used in various industries to improve surfaces and mechanical properties of diverse materials, such as paints and coatings, plastics, synthetic rubber, adhesives, sealants, or insulation materials. However, recent studies have shown that nano-sized silica (nano-silica) (10 nm in diameter) can generate adverse effects, like liver injury and inflammation. The cytotoxicity and genotoxicity of nano-silica were investigated using the dye exclusion assay, comet assay, and mouse lymphoma thymidine kinase (tk $^{+/−}$) mouse lymphoma assay (MLA). IC$_{20}$ of nano-silica in L5178Y cells was determined to be of 2,441.41 μg/mL and 2,363.28 μg/mL without and with S-9, respectively. Also IC$_{20}$ of nano-silica in BEAS-2B cells was determined to be of 2,324.23 μg/mL and 537.11 μg/mL without and with S-9, respectively. In the comet assay, treating L5178Y cells and BEAS-2B cells with nanosilica treatment induced approximately 2-fold increases in tail moment (P<0.05) without and with S-9. Also, the mutant frequencies in the nano-silica treated L5178Y cells were not significantly increased compared to the solvent controls. The results of this study indicate that nano-silica can cause primary DNA damage and cytotoxicity but not mutagenicity in cultured mammalian cells.
Starting Page 7
Ending Page 13
Page Count 7
File Format PDF
ISSN 20059752
Journal Toxicology and Environmental Health Sciences
Volume Number 3
Issue Number 1
Language English
Publisher Korean Society of Environmental Risk Assessment and Health Science
Publisher Date 2011-06-24
Publisher Place Springer
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Nanoparticle Nano-silica Comet assay Mouse lymphoma assay (MLA) Cytotoxicity Genotoxicity Pharmacology/Toxicology Environmental Health
Content Type Text
Resource Type Article
Subject Health, Toxicology and Mutagenesis Toxicology
  • About
  • Disclaimer
  • Feedback
  • Sponsor
  • Contact
  • Chat with Us
About National Digital Library of India (NDLI)
NDLI logo

National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.

Learn more about this project from here.

Disclaimer

NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.

Feedback

Sponsor

Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.

Contact National Digital Library of India
Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302
See location in the Map
03222 282435
Mail: support@ndl.gov.in
Sl. Authority Responsibilities Communication Details
1 Ministry of Education (GoI),
Department of Higher Education
Sanctioning Authority https://www.education.gov.in/ict-initiatives
2 Indian Institute of Technology Kharagpur Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project https://www.iitkgp.ac.in
3 National Digital Library of India Office, Indian Institute of Technology Kharagpur The administrative and infrastructural headquarters of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
4 Project PI / Joint PI Principal Investigator and Joint Principal Investigators of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
Prof. Saswat Chakrabarti  will be added soon
5 Website/Portal (Helpdesk) Queries regarding NDLI and its services support@ndl.gov.in
6 Contents and Copyright Issues Queries related to content curation and copyright issues content@ndl.gov.in
7 National Digital Library of India Club (NDLI Club) Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach clubsupport@ndl.gov.in
8 Digital Preservation Centre (DPC) Assistance with digitizing and archiving copyright-free printed books dpc@ndl.gov.in
9 IDR Setup or Support Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops idr@ndl.gov.in
I will try my best to help you...
Cite this Content
Loading...