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| Content Provider | Springer Nature Link |
|---|---|
| Author | Choi, Han Saem Kim, Youn Jung Song, Mee Song, Mi Kyung Ryu, Jae Chun |
| Copyright Year | 2011 |
| Abstract | Nanomaterials are defined by the U.S. National Nanotechnology Initiative as materials that have at least one dimension in the 1- to 100-nm range. Due to their unique physical and chemical characteristics, nanotechnology has become one of the leading technologies over the past 10 years. This study represents data on genotoxic effects of nanoparticles and their application for assessing human health risks. Silica (SiO$_{2}$) is a multi-functional ceramic material that is being used in various industries to improve surfaces and mechanical properties of diverse materials, such as paints and coatings, plastics, synthetic rubber, adhesives, sealants, or insulation materials. However, recent studies have shown that nano-sized silica (nano-silica) (10 nm in diameter) can generate adverse effects, like liver injury and inflammation. The cytotoxicity and genotoxicity of nano-silica were investigated using the dye exclusion assay, comet assay, and mouse lymphoma thymidine kinase (tk $^{+/−}$) mouse lymphoma assay (MLA). IC$_{20}$ of nano-silica in L5178Y cells was determined to be of 2,441.41 μg/mL and 2,363.28 μg/mL without and with S-9, respectively. Also IC$_{20}$ of nano-silica in BEAS-2B cells was determined to be of 2,324.23 μg/mL and 537.11 μg/mL without and with S-9, respectively. In the comet assay, treating L5178Y cells and BEAS-2B cells with nanosilica treatment induced approximately 2-fold increases in tail moment (P<0.05) without and with S-9. Also, the mutant frequencies in the nano-silica treated L5178Y cells were not significantly increased compared to the solvent controls. The results of this study indicate that nano-silica can cause primary DNA damage and cytotoxicity but not mutagenicity in cultured mammalian cells. |
| Starting Page | 7 |
| Ending Page | 13 |
| Page Count | 7 |
| File Format | |
| ISSN | 20059752 |
| Journal | Toxicology and Environmental Health Sciences |
| Volume Number | 3 |
| Issue Number | 1 |
| Language | English |
| Publisher | Korean Society of Environmental Risk Assessment and Health Science |
| Publisher Date | 2011-06-24 |
| Publisher Place | Springer |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanoparticle Nano-silica Comet assay Mouse lymphoma assay (MLA) Cytotoxicity Genotoxicity Pharmacology/Toxicology Environmental Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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