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Molecular & Cellular Toxicology : Volume 7, Issue 3, September 2011

Molecular & Cellular Toxicology : Volume 7, Issue 2, June 2011

Molecular & Cellular Toxicology : Volume 7, Issue 1, March 2011

Molecular & Cellular Toxicology : Volume 6

Oxidative stress and apoptosis induced by ZnO nanoparticles in HaCaT cells

Content Provider	Springer Nature Link
Author	Bae, Hyun Cheol Ryu, Hwa Jung Jeong, Sang Hoon Lee, Eun Young Park, Yoon Hee Lee, Kyung Goo Choi, Byeong Hyeok Maeng, Eun Ho Kim, Meyoung Kon Son, Sang Wook
Copyright Year	2011
Abstract	Zinc oxide (ZnO) nanoparticles (NPs) are used in the cosmetic industry in cosmetics and sunscreen. ZnO NPs have been reported to elicit various adverse cellular effects, including cytotoxicity. However, the underlying mechanisms of these adverse effects have not been fully characterized. To investigate the potential of cytotoxicity induced by ZnO NPs, we evaluated cytosolic reactive oxygen species levels in human keratinocyte HaCaT cells treated with ZnO NPs having different surface charges and particle sizes. A short period of treatment (30 min) with 100 nm ZnO NPs resulted in a greater increase of cytosolic ROS levels, compared to treatment with 20 nm ZnO NPs at the same concentration. During a long period of treatment (24 h) with ZnO NPs, intracellular ROS was increased in cells treated with 20 μg/mL 20 nm (+/−) charged ZnO. No significant difference according to differences in surface charge was observed. In addition, total levels of caspase-7 and PARP were decreased by ZnO NPs. These results demonstrated that ZnO NPs could induce ROS mediated apoptosis.
Starting Page	333
Ending Page	337
Page Count	5
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	7
Issue Number	4
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2012-01-04
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ZnO Cytotoxicity ROS Keratinocyte Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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