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Gene expression in zebrafish embryos following exposure to TiO$_{2}$ nanoparticles

Content Provider	Springer Nature Link
Author	Yeo, Min Kyeong Kim, Hyo Eun
Copyright Year	2010
Abstract	In this study, we investigated the effects of TiO$_{2}$ nanoparticles, potential biological toxins, on zebrafish (Danio rerio) embryogenesis. We exposed zebrafish embryos to TiO$_{2}$ particles of three different diameters (12–14 nm, 80–100 nm, 150–200 nm) and compared the acute responses of the embryos during embryogenesis. Scanning electron microscope (SEM) images demonstrated that 12–14 nm TiO$_{2}$ particles were small ball types, while 80–100 nm TiO$_{2}$ particles were square and ball types. Square layers were observed in the 150–200 nm TiO$_{2}$ particles. The zebrafish morphants survived that exposure to the TiO$_{2}$ nanoparticles exhibited incomplete notochord formation, with epidermal injuries observed in larvae exposed to 12–14 nm and 150–200 nm particles. In microarray analysis, several genes involved in immune response, tumor necrosis factor, and endocytosis and its regulation were differentially expressed in accordance to the nanoparticle size. Gene expression in embryos exposed to 12–14 nm particles was significantly upregulated in comparison to the control group and embryos exposed to other particle sizes. The results of the present study suggest that TiO$_{2}$ nanoparticles 12–14 nm in size have toxic effects on zebraish development. TiO$_{2}$ nanoparticles of larger sizes (80–100 nm, 150–200 nm) exhibit different types of genetic effects.
Starting Page	97
Ending Page	104
Page Count	8
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	6
Issue Number	1
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2010-05-02
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nanometer-sized TiO$_{2}$ Zebrafish Gene expression Regulation endocytosis Immune response Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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