NDLI: Metabolic gene expression profiling of Zebrafish embryos exposed to silver nanocolloids and nanotubes

Content Provider	Springer Nature Link
Author	Park, Hyung Geun Yeo, Min Kyeong
Copyright Year	2014
Abstract	Nanosilver is produced in various shapes, size and coatings to increase its nanomaterial effects. However, the nanotoxicity related with the physiochemical properties of nanomaterials. When nanomaterials attach, reacted or be though the cell membrane, the first barriers they face are cell proteins (e.g., receptors, enzymes, and carriers). Nanomaterials could affect metabolic mechanisms through their reaction with cell proteins. Therefore, this study analyzed changes in metabolic processes to identify corresponding changes in molecular functions and biological processes. We compared the gene expression profiling results of zebrafish embryos exposed to silver nanocolloids (Ag NCs, 10 μg/L) and silver nanotubes (Ag NTs, 1 μg/L); the results revealed that 198 genes were upregulated and 99 downregulated by Ag NCs and Ag NTs. The major genes of molecular function were associated with binding and catalytic activity, and the related genes of biological processes were involved in nucleobase-containing compound and protein metabolic processes. This study suggests that the two types of nanosilver caused similar patterns of metabolic process change regardless of nanosilver shape.
Starting Page	401
Ending Page	409
Page Count	9
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	10
Issue Number	4
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2015-01-20
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Silver nanocolloids Silver nanotubes Zebrafish embryos Metabolic process Gene expression Cell Biology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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