NDLI: Potential of a Funalia trogii laccase enzyme as an anticancer agent

Content Provider	Springer Nature Link
Author	Rashid, Shazia Unyayar, Ali Mazmanci, Mehmet Ali McKeown, Stephanie R. Worthington, Jenny Banat, Ibrahim M.
Copyright Year	2014
Abstract	Funalia trogii extract has been reported to have antitumour properties, selectively killing cancer cells without affecting normal cells in vitro; the extract has also been found to be effective in reducing tumour growth in vivo. The present study was carried out to identify the bioactive constituents in the extract; in particular, the enzyme components (laccase and peroxidase). Results confirmed that laccase (molecular size 65 kDa) was one of the bioactive agents present in the extract. Native gels were stained for protein and the excised bands were analysed using Mascot and Blastp search tools. Laccase was confirmed to be one of the protein bands; however, the identity of the second band could not be confirmed. Also, the role of enzyme peroxidase could not be established in the cytotoxicity of the F. trogii extract. In conclusion, the results indicate that laccase may be one of the potential bioactive components of F. trogii extract, and further studies are required to understand its course of action in conferring cytotoxic properties. The ability to produce these enzymes under liquid fermentation conditions in relatively pure form lends itself for large scale industrial production.
Starting Page	175
Ending Page	183
Page Count	9
File Format	PDF
ISSN	15904261
Journal	Annals of Microbiology
Volume Number	65
Issue Number	1
e-ISSN	18692044
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-03-25
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Funalia trogii Anticancer Antitumor Laccase Bioactive Fermentation Microbiology Microbial Genetics and Genomics Microbial Ecology Fungus Genetics Medical Microbiology Applied Microbiology
Content Type	Text
Resource Type	Article
Subject	Applied Microbiology and Biotechnology

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