NDLI: Altered Cerebellar Activity in Visceral Pain-Related Fear Conditioning in Irritable Bowel Syndrome

Content Provider	Springer Nature Link
Author	Claassen, J. Labrenz, F. Ernst, T.M. Icenhour, A. Langhorst, J. Forsting, M. Timmann, D. Elsenbruch, S.
Copyright Year	2016
Abstract	There is evidence to support a role of the cerebellum in emotional learning processes, which are demonstrably altered in patients with chronic pain. We tested if cerebellar activation is altered during visceral pain-related fear conditioning and extinction in irritable bowel syndrome (IBS). Cerebellar blood oxygenation level-dependent (BOLD) data from N = 17 IBS patients and N = 21 healthy controls, collected as part of a previous fMRI study, was reanalyzed utilizing an advanced normalizing method of the cerebellum. The differential fear conditioning paradigm consisted of acquisition, extinction, and reinstatement phases. During acquisition, two visual conditioned stimuli (CS) were presented either paired (CS+) or unpaired (CS−) with painful rectal distension as unconditioned stimulus (US). In the extinction phase, the CS+ and CS− were presented without US. For reinstatement, unpaired US presentations were followed by unpaired CS+ and CS− presentations. Group differences in cerebellar activation were analyzed for the contrasts CS+ > CS− and CS− > CS+. During acquisition, IBS patients revealed significantly enhanced cerebellar BOLD responses to pain-predictive (CS+) and safety (CS−) cues compared to controls (p < 0.05, family-wise error corrected). Increased activation was found in three main clusters, including the vermis (maximum in vermal lobule VI), intermediate cerebellum (maximum in lobule VIII), and the posterolateral cerebellar hemisphere (maximum in lobule VI). Areas overlapped for the contrasts CS+ > CS− and CS− > CS+. Group differences were most prominent in the contrast CS− > CS+. During extinction and reinstatement, no significant group differences were found. During visceral pain-related fear conditioning, IBS patients showed increased activations in circumscribed areas of the medial, intermediate, and lateral cerebellum. These areas are involved in autonomic, somatosensory, and cognitive functions and likely contribute to the different aspects of pain-related fear. The cerebellum contributes to altered pain-related fear learning in IBS.
Starting Page	508
Ending Page	517
Page Count	10
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	16
Issue Number	2
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2016-10-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Visceral pain Cerebellum Irritable bowel syndrome Fear conditioning Anticipation Extinction Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cerebellar Contributions to Different Phases of Visceral Aversive Extinction Learning

Contributions of the Cerebellum to Disturbed Central Processing of Visceral Stimuli in Irritable Bowel Syndrome

Cerebellar Contribution to Context Processing in Extinction Learning and Recall

Posterior Fossa Syndrome After Cerebellar Stroke

Cerebellar Sequencing: a Trick for Predicting the Future

Developmental Cerebellar Cognitive Affective Syndrome in Ex-preterm Survivors Following Cerebellar Injury

Cerebellar Clustering and Functional Connectivity During Pain Processing

Behavioural aspects of cerebellar function in adults with Asperger syndrome

Cerebellar Stimulation in Ataxia

Altered Cerebellar Activity in Visceral Pain-Related Fear Conditioning in Irritable Bowel Syndrome

Similar Documents

Cerebellar Contributions to Different Phases of Visceral Aversive Extinction Learning

Contributions of the Cerebellum to Disturbed Central Processing of Visceral Stimuli in Irritable Bowel Syndrome

Cerebellar Contribution to Context Processing in Extinction Learning and Recall

Posterior Fossa Syndrome After Cerebellar Stroke

Cerebellar Sequencing: a Trick for Predicting the Future

Developmental Cerebellar Cognitive Affective Syndrome in Ex-preterm Survivors Following Cerebellar Injury

Cerebellar Clustering and Functional Connectivity During Pain Processing

Behavioural aspects of cerebellar function in adults with Asperger syndrome

Cerebellar Stimulation in Ataxia

Altered Cerebellar Activity in Visceral Pain-Related Fear Conditioning in Irritable Bowel Syndrome