NDLI: Cerebellar Clustering and Functional Connectivity During Pain Processing

Content Provider	Springer Nature Link
Author	Diano, M. D’Agata, F. Cauda, F. Costa, T. Geda, E. Sacco, K. Duca, S. Torta, D. M. Geminiani, G. C.
Copyright Year	2015
Abstract	The cerebellum has been traditionally considered a sensory-motor structure, but more recently has been related to other cognitive and affective functions. Previous research and meta-analytic studies suggested that it could be involved in pain processing. Our aim was to distinguish the functional networks subserved by the cerebellum during pain processing. We used functional magnetic resonance imaging (fMRI) on 12 subjects undergoing mechanical pain stimulation and resting state acquisition. For the analysis of data, we used fuzzy c-mean to cluster cerebellar activity of each participant during nociception. The mean time courses of the clusters were used as regressors in a general linear model (GLM) analysis to explore brain functional connectivity (FC) of the cerebellar clusters. We compared our results with the resting state FC of the same cluster and explored with meta-analysis the behavior profile of the FC networks. We identified three significant clusters: cluster V, involving the culmen and quadrangular lobules (vermis IV-V, hemispheres IV-V-VI); cluster VI, involving the posterior quadrangular lobule and superior semilunar lobule (hemisphere VI, crus 1, crus 2), and cluster VII, involving the inferior semilunar lobule (VIIb, crus1, crus 2). Cluster V was more connected during pain with sensory-motor areas, cluster VI with cognitive areas, and cluster VII with emotional areas. Our results indicate that during the application of mechanical punctate stimuli, the cerebellum is not only involved in sensory functions but also with areas typically associated with cognitive and affective functions. Cerebellum seems to be involved in various aspects of nociception, reflecting the multidimensionality of pain perception.
Starting Page	343
Ending Page	356
Page Count	14
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	15
Issue Number	3
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2015-07-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebellum Pain Fuzzy clustering Functional connectivity Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dyslexic Children Show Atypical Cerebellar Activation and Cerebro-Cerebellar Functional Connectivity in Orthographic and Phonological Processing

Coupling between cerebellar hemispheres: Behavioural, anatomic, and functional data

Interhemispheric Connectivity Characterizes Cortical Reorganization in Motor-Related Networks After Cerebellar Lesions

Cerebellar Sequencing: a Trick for Predicting the Future

Cerebellar Control on Prefrontal-Motor Connectivity During Movement Inhibition

Coupling between cerebellar hemispheres and sensory processing

Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations

Targeting the Cerebellum by Noninvasive Neurostimulation: a Review

Cerebellar Stimulation in Ataxia

Cerebellar Clustering and Functional Connectivity During Pain Processing

Similar Documents

Dyslexic Children Show Atypical Cerebellar Activation and Cerebro-Cerebellar Functional Connectivity in Orthographic and Phonological Processing

Coupling between cerebellar hemispheres: Behavioural, anatomic, and functional data

Interhemispheric Connectivity Characterizes Cortical Reorganization in Motor-Related Networks After Cerebellar Lesions

Cerebellar Sequencing: a Trick for Predicting the Future

Cerebellar Control on Prefrontal-Motor Connectivity During Movement Inhibition

Coupling between cerebellar hemispheres and sensory processing

Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations

Targeting the Cerebellum by Noninvasive Neurostimulation: a Review

Cerebellar Stimulation in Ataxia

Cerebellar Clustering and Functional Connectivity During Pain Processing