NDLI: Unveiling of miRNA Expression Patterns in Purkinje Cells During Development

Content Provider	Springer Nature Link
Author	Pieczora, Lukas Stracke, Lara Vorgerd, Matthias Hahn, Stephan Theiss, Carsten Theis, Verena
Copyright Year	2016
Abstract	MicroRNAs (miRNAs) are short noncoding RNAs of 19–25 nucleotides in length that regulate gene expression at the post-transcriptional level. Dysregulation of miRNAs is associated with many disorders and neurodegenerative diseases affecting numerous different pathways and processes, of which many have not yet been completely explored. Recent studies even indicate a crucial role of miRNAs during brain development, with differential expression patterns of several miRNAs seen in both developing and mature cells. A miRNA profiling in brain tissue and the fundamental understanding of their effects might optimize the therapeutical treatment of various neurological disorders. In this study, we performed miRNA array analysis of enriched cerebellar Purkinje cell (PC) samples from both young and mature rat cerebella. We used laser microdissection (LMD) to enrich PC for a highly specific miRNA profiling. Altogether, we present the expression profile of at least 27 miRNAs expressed in rat cerebellar PC and disclose a different expression pattern of at least three of these miRNAs during development. These miRNAs are potential candidates for the regulation and control of cerebellar PC development, including neuritic and dendritic outgrowth as well as spine formation.
Starting Page	376
Ending Page	387
Page Count	12
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	16
Issue Number	2
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2016-07-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brain development Central nervous system Cerebellum MicroRNA Purkinje cell Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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