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Pathology & Oncology Research : Volume 4, Issue 1, March 1998

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Cytokine sensitivity of metastatic human melanoma cell lines -simultaneous inhibition of proliferation and enhancement of gelatinase activity

Content Provider	Springer Nature Link
Author	LadÁnyi, Andrea Nagy, Julianna O Jeney, András TÍMÁr, József
Copyright Year	1998
Abstract	The effect of a panel of cytokines on the proliferation and type IV collagenase production was studied in four melanoma cell lines of different origin, tumorigenicity and metastatic capacity. TGF-β, TNF-α and to a lesser extent, IL-lα exhibited antiproliferative effect on the cell lines, with some lines showing varying degree of resistance. The sensitivity did not correlate directly with the origin or the biological behavior of the tumor lines, suggesting that cytokine resistance of advanced stage melanoma cells may be relative. IL.-2- IL.-10 and IL.-12 displayed little or no effect on proliferation. The effect of cytokines on metalloproteinase production showed a cell line dependent pattern. Interestingly, those cytokines that exhibited the most pronounced antiproliferative activity, also proved most effective in stimulating collagenase secretion, often simultaneously, in the same line. The results indicate that pleiotropic cytokines can have positive and negative effects simultaneously on various steps of tumor progression.
Starting Page	108
Ending Page	114
Page Count	7
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	4
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	melanoma cytokines proliferation metalloproteinases Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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