NDLI: Biomolecular cytokine therapy

Content Provider	Springer Nature Link
Author	Bencsáth, Márta Blaskovits, Aladár Borvendég, Jás
Copyright Year	2003
Abstract	As for the chronicity of inflammatory-immune diseases, the medication of them needs to be longterm and thus, quite safe with respect to side effects due to drug actions. Therapy of these diseases includes steroid and non steroid anti-inflammatories given in monotherapy or in combination with cytotoxic antimetabolites. Longterm administration of these active substances cumulate in side effects, not to speak of the probability of developing unresponsiveness to the drug in use. In principle, the earlier the intervention, the better the outcome of medication in therapy. In harmony with this principle, biopharmacology focuses on specific targets in early (acute) phase of inflammatory-immune diseases. One of these targets is the proinflammatory cascade of cytokines (IL1β, IL6, IL8, IL12, TNFα). Among them, the overproduction of tumor necrosis factor (TNFα) is suggested to orchestrate and escalate the disease phenotype. Hence, targeting of TNFα may restrict or stop the propagation of pathological reactions. TNFα in its excess can be captured at transcription, translation, secretion levels as well as in the extracellular soluble form. This latter approach is supported by clinical records emphasizing the use of recombinant antibodies and soluble receptors in trapping extra amounts of TNFα This review serves as an illustration for the efficacy and safety of infliximab (antibody) and etanercept (soluble receptor) in the example of rheumatoid arthritis (RA).
Starting Page	24
Ending Page	29
Page Count	6
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	9
Issue Number	1
Language	English
Publisher	Springer Netherlands
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	chronic inflammation therapy cytokines infliximab etanercept Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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