NDLI: Cathepsin D immunoreactivity in ovarian cancer: Correlation with prognostic factors

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Pathology & Oncology Research : Volume 4, Issue 1, March 1998

Pathology & Oncology Research : Volume 3

Cathepsin D immunoreactivity in ovarian cancer: Correlation with prognostic factors

Content Provider	Springer Nature Link
Author	Athanassiadou, Pauline Sakellariou, Vasiliki Petrakakou, Efthalia Athanassiades, Peter Zerva, Cherry Liossi, Anna Michalas, Stylias
Copyright Year	1998
Abstract	In view of the somewhat inconclusive nature of reports of the role of Cathepsin D (Cath D) in ovarian carcinomas and its relationship with various other parameters of malignancy, the present study was performed to aid in the further clarification of this role. One hundred freshly resected primary ovarian carcinomas of various histological types were studied for ER, PR and Cath D status and the results examined with respect to menopausal status, histology, size and lymph node invasion. In our series Cath D positivity was more frequent in serous than in other types of ovarian cancer, but this positivity was not related to the frequency of lymph node invasion regardless of the size of the tumor. Furthermore, no association was observed between Cath D positivity and ER or PR status of the tumors or the menopausal state of the patients. The reported prognostic value of Cath D, ER and PR is discussed as well as the distinction between tumor invasion by lymphatic channels and direct interstitial infiltration. It was concluded that Cath D may not play role in the former mode but, as might be expected from its proteolytic properties, in the local spread by means of tissue destruction.
Starting Page	103
Ending Page	107
Page Count	5
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	4
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	ovarian carcinoma cathepsin D immunocytochemistry prognostic factors Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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