NDLI: The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors

Content Provider	Springer Nature Link
Author	Rusz, Orsolya Pál, Margit Szilágyi, Éva Rovó, László Varga, Zoltán Tomisa, Bernadett Fábián, Gabriella Kovács, Levente Nagy, Olga Mózes, Petra Reisz, Zita Tiszlavicz, László Deák, Péter Kahán, Zsuzsanna
Copyright Year	2016
Abstract	DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel, cisplatin and 5-fluorouracil followed by concomitant chemoradiotherapy (ChRT) or radiotherapy (RT) alone. The volumetric metabolic therapeutic response was determined by [18F]FDG-PET/CT. In the tumor and matched normal tissues collected before treatment, the gene expressions were examined via the quantitative real-time polymerase chain reaction (qRT-PCR). The down-regulation of TP53 was apparently associated with a poor response to iChT, its up-regulation with complete regression in 2 cases. 7 cases with down-regulated REV1 expression showed complete regression after ChRT/RT, while 1 case with REV1 overexpression was resistant to RT. The overexpression of WRN was an independent predictor of tumor relapse. Our results suggest that an altered expression of REV1 predicts sensitivity to RT, while WRN overexpression is an unfavorable prognostic factor.
Starting Page	253
Ending Page	264
Page Count	12
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	23
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-07-13
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Head and neck cancer Chemosensitivity Radiosensitivity DNA damage response Gene expression Cancer Research Oncology Pathology Immunology Biomedicine
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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