NDLI: Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer

Content Provider	Springer Nature Link
Author	Demokan, Semra Demir, Deniz Suoglu, Yusufhan Kiyak, Erkan Akar, Ugur Dalay, Nejat
Copyright Year	2005
Abstract	Inherited polymorphisms in the genes controlling the cell cycle or functioning in the DNA repair mechanisms may impair their function and contribute to genetic susceptibility. Abnormalities in the DNA repair have been reported in head and neck cancer. The XRCC1 gene functions in singlestrand break and base excision repair processes. In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399G1n were investigated in 95 patients with head and neck carcinoma. The polymorphic regions were amplified by PCR followed by digestion with methylation-specific restriction enzymes, and analyzed electrophoretically. Genotype and allele frequencies were calculated, and association with cancer risk or clinical parameters was investigated. No association was observed between the genotypes and head and neck cancer for either polymorphism. Distribution of the alleles did not significantly differ between the patients and the control group. A significant association was only found for the Trp194 allele among the smoking individuals. Our data indicate that the Arg194Trp and Arg399G1n polymorphisms do not confer a significant risk for head and neck carcinogenesis.
Starting Page	22
Ending Page	25
Page Count	4
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	11
Issue Number	1
Language	English
Publisher	Springer Netherlands
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	polymorphism XRCC1 head and neck cancer Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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