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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tan, Cheng Qian, Xia Ge, Yangyang Yang, Baixia Wang, Feng Guan, Zhifeng Cai, Jing |
| Copyright Year | 2016 |
| Abstract | To evaluate the radiosensitization of Oroxylin A on esophageal carcinoma cell as well as the optimal scheduling of Oroxylin A and radiotherapy (RT). Cell proliferation was estimated by a CCK8 assay. Radiosensitization was evaluated by a clonogenic survival assay. The progressions of Cell apoptosis and Cell cycle were investigated by flow cytometry. Expressions of survivin and cell cycle regulators were evaluated by Western blot analysis. A dose-dependent cell survival reduction was found in response to radiation with or without Oroxylin A. The apoptosis rates were remarkably dose-dependent higher in combination groups than in either Oroxylin A or radiation alone group. Besides, Oroxylin A could obviously radiosensitize ESCC cells by arresting tumor cells in G2/M phase and regulating cyclin B1 and Cdc 2 protein expression. Oroxylin A could be a promising radiosensitizer for esophageal squamous cell carcinoma by inducing G2/M phase blocking and activating cell apoptosis. |
| Starting Page | 323 |
| Ending Page | 328 |
| Page Count | 6 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 23 |
| Issue Number | 2 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2016-09-02 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Oroxylin A Radiosensitization ESCC Apoptosis G2/M arrest Cancer Research Oncology Pathology Immunology Biomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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