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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ikegawa, Shuntaro Doki, riko Kaito, Satoshi Kurosawa, Shuhei Sakaguchi, Masahiro Harada, Kaito Yamamoto, Keita Hi, Yutaro Shingai, Naoki Seo, Yasushi Watanabe, Daisuke Hagi, Takeshi Yoshioka, Kosuke Watakabe, Kyoko Igarashi, Aiko Najima, Yuho Kobayashi, Takeshi Kakihana, Kazuhiko Sakamaki, Hisashi Ohashi, Kazuteru |
| Copyright Year | 2016 |
| Abstract | Recent reports suggested that central nervous system (CNS) involvement (CNS+) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not an independent predictor of survival after allo-HSCT. However, these studies did not analyze minimal residual disease in the CNS at the time of allo-HSCT. We evaluated the effect of residual CNS+ on the transplant outcomes of 214 AML patients in a single institution. Twenty-one (10%) patients were diagnosed with CNS+ prior to allo-HSCT. Of these, 13 patients had CNS disease at the time of allo-HSCT. The patients in CNS+ AML remission at the time of allo-HSCT had better overall survival (OS) than the patients who were not in remission (2-year OS: 55% vs. 7.7%, p = 0.0001). In multivariate analyses, CNS+ at the time of allo-HSCT (hazard ratio (HR), 1.9; 95% confidence interval (CI), 1.05–3.59; p = 0.04), age over 50 years at the time of allo-HSCT, and non-complete remission disease status in bone marrow at the time of allo-HSCT were independent adverse factors for OS. However, a prior history of CNS+ before allo-HSCT did not independently affect OS (HR, 1.27; 95% CI 0.53–2.07; p = 0.6). Early diagnosis and eradication of CNS+ at the time of allo-HSCT may be necessary to improve the outcome for patients with CNS+ AML. |
| Starting Page | 433 |
| Ending Page | 437 |
| Page Count | 5 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 23 |
| Issue Number | 2 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2016-12-21 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Central nervous system involvement Allogeneic hematopoietic stem cell transplantation Acute myeloid leukemia Cancer Research Oncology Pathology Immunology Biomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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