NDLI: The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia

Content Provider	Springer Nature Link
Author	Su, Yousong Ding, Wenhua Xing, Mengjuan Qi, Dake Li, Zezhi Cui, Donghong
Copyright Year	2016
Abstract	Although previous studies showed the reduced risk of cancer in patients with schizophrenia, whether patients with schizophrenia possess genetic factors that also contribute to tumor suppressor is still unknown. In the present study, based on our previous microarray data, we focused on the tumor suppressor genes TXNIP and AF1q, which differentially expressed in patients with schizophrenia. A total of 413 patients and 578 healthy controls were recruited. We found no significant differences in genotype, allele, or haplotype frequencies at the selected five single nucleotide polymorphisms (SNPs) (rs2236566 and rs7211 in TXNIP gene; rs10749659, rs2140709, and rs3738481 in AF1q gene) between patients with schizophrenia and controls. However, we found the association between the interaction of TXNIP and AF1q with schizophrenia by using the MDR method followed by traditional statistical analysis. The best gene-gene interaction model identified was a three-locus model TXNIP (rs2236566, rs7211)-AF1q (rs2140709). After traditional statistical analysis, we found the high-risk genotype combination was rs2236566 (GG)-rs7211(CC)-rs2140709(CC) (OR = 1.35 [1.03–1.76]). The low-risk genotype combination was rs2236566 (GT)-rs7211(CC)-rs2140709(CC) (OR = 0.67 [0.49–0.91]). Our finding suggested statistically significant role of interaction of TXNIP and AF1q polymorphisms (TXNIP-rs2236566, TXNIP-rs7211, and AF1q-rs2769605) in schizophrenia susceptibility.
Starting Page	4806
Ending Page	4812
Page Count	7
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	54
Issue Number	6
e-ISSN	15591182
Language	English
Publisher	Springer US
Publisher Date	2016-08-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TXNIP AFq1 Interaction Schizophrenia Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Glutamate receptor genes : Susceptibility factors in schizophrenia and depressive disorders?

Cell Biology of the BLOC-1 Complex Subunit Dysbindin, a Schizophrenia Susceptibility Gene

MtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia

Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population

Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis

Chromosomal Distribution of Schizophrenia Susceptibility Loci

Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia

On Rita Levi-Montalcini

Erratum to: Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress

The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia

Similar Documents

Glutamate receptor genes : Susceptibility factors in schizophrenia and depressive disorders?

Cell Biology of the BLOC-1 Complex Subunit Dysbindin, a Schizophrenia Susceptibility Gene

MtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia

Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population

Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis

Chromosomal Distribution of Schizophrenia Susceptibility Loci

Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia

On Rita Levi-Montalcini

Erratum to: Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress

The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia