NDLI: Associations of rs3740677 within GAB2 Gene with LOAD in Chinese Han Population

Content Provider	Springer Nature Link
Author	Zheng, Jing Yu Wang, Hui Fu Wan, Yu Tan, Meng Shan Tan, Chen Chen Tan, Lin Zhang, Wei Zheng, Zhan Jie Kong, Ling Li Wang, Zi Xuan Tan, Lan Yu, Jin Tai
Copyright Year	2016
Abstract	GRB2-associated binding protein 2 (GAB2) has been identified as a crucial factor in Alzheimer’s disease (AD), and ten common variants within GAB2 have been detected to be associated with AD onset risk in genome-wide association studies (GWAS). Here, we first screened a common locus (rs3740677) in 3′ UTR of GAB2 sequence which is targeted by the miRNA-185 and initiatively explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case–control study from Chinese Han populations (992 LOAD patients and 1358 healthy subjects). Eventually, the genotype (P = 0.024) and allele (P = 0.008) distribution of rs3740677 showed significant difference between LOAD and control group, and we observed a significant association of T allele in rs3740677 with LOAD risk in multivariate analysis and it decreased the risk for LOAD (dominant: OR = 0.831, 95 % CI = 0.702–0.983, P = 0.031; additive: OR = 0.855, 95 % CI = 0.745–0.983, P = 0.027) adjusted for age, gender, and APOE ε4 status. Our study further confirmed the association of GAB2 and AD. However, the absolute and correct association of rs3740677 with AD still required more investigations in diverse regions and ethnics.
Starting Page	4015
Ending Page	4020
Page Count	6
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	54
Issue Number	6
e-ISSN	15591182
Language	English
Publisher	Springer US
Publisher Date	2016-06-17
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	GAB2 Polymorphism miRNA-185 Alzheimer’s disease Association study Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

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