NDLI: Glutamate receptor genes : Susceptibility factors in schizophrenia and depressive disorders?

Content Provider	Springer Nature Link
Author	Schiffer, Hans H.
Copyright Year	2002
Abstract	Schizophrenia, depression, and bipolar disorder are three major neuropsychiatric disorders that are among the leading causes of disability and have enormous economic impacts on our society. Although several neurotransmitter systems have been suggested to play a role in their etiology, we still have not identified any gene or molecular mechanism that might lead to genetic susceptibility for or protection against these neuropsychiatric disorders. The glutamatergic receptor system, and in particular the N-methyl-D-aspartate (NMDA) receptor complex, has long been implicated in their etiology. I review the current molecular evidence that supports a critical role for the glutamatergic receptor system in schizophrenia and the potential involvement of this receptor system in depression and bipolar disorder. It is likely that mutations in glutamate receptor genes might alter the risk of developing one of these disorders. Potential future research directions designed to identify these mutations and to elucidate their effect on mental health will be discussed.
Starting Page	191
Ending Page	212
Page Count	22
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	25
Issue Number	2
e-ISSN	15591182
Language	English
Publisher	Humana Press
Publisher Date	2002-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurobiology Neurology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

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