NDLI: Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain

Content Provider	Springer Nature Link
Author	Chen, Sheng Luo, Guang Rui Li, Ting Liu, Ting Xi Le, Weidong
Copyright Year	2013
Abstract	Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive (TH$^{+}$) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of TH$^{+}$ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped TH$^{+}$ cells in the posterior tuberculum area and some small round TH$^{+}$ cells in the pretectum area, but not with large pear-shaped TH$^{+}$ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a2$^{ + }$ cells were localized next to the dorsal side of TH$^{+}$ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases.
Starting Page	719
Ending Page	723
Page Count	5
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	51
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Springer US
Publisher Date	2013-07-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nr4a2 Tyrosine hydroxylase Nestin Adult zebrafish brain Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

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