NDLI: Distinct Expression of Mas1-Related G-Protein-Coupled Receptor B4 in Dorsal Root and Trigeminal Ganglia—Implications for Altered Behaviors in Acid-Sensing Ion Channel 3-Deficient Mice

Content Provider	Springer Nature Link
Author	Huang, Ya Han Chang, Chin Yu Chen, Chih Cheng Yang, Chih Dong Sun, Wei Hsin
Copyright Year	2013
Abstract	Mas1-related G-protein-coupled receptors (Mrgprs), comprising more than 50 distinct members, are specifically expressed in primary sensory neurons. Reflecting the diversity and specificity of stimuli they detect, Mrgprs are involved in pain, touch, and itch-related behaviors. Sensory–neuron-specific acid-sensing ion channel 3 (ASIC3) is essential for touch and inflammatory pain, but mice lacking ASIC3 have complex behavioral alterations in various modalities of pain and touch. To understand whether Mrgprs are involved in complex behavioral alterations found in ASIC3-deficient mice, we examined Mrgpr gene expression in ASIC3$^{−/−}$ mice. Only MrgprB4 expression has shown significant change. MrgprB4 expression was increased in ASIC3$^{−/−}$ dorsal root ganglia (DRG) but decreased in ASIC3$^{−/−}$ trigeminal ganglia. The distinct alterations in DRG and trigeminal ganglia imply that MrgprB4 could have multiple functions. Given that MrgprB4 is expressed in neurons that may detect gentle touch and that ASIC3$^{−/−}$ mice have altered sensitivity of mechanoreceptors for light touch, the expression change of MrgprB4 is more likely related to the altered touch behaviors of ASIC3$^{−/−}$ mice.
Starting Page	820
Ending Page	834
Page Count	15
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	51
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Springer US
Publisher Date	2013-07-31
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dorsal root ganglion Trigeminal ganglion Mas1-related G-protein-coupled receptor B4 ASIC3 Nociceptors Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

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