NDLI: The Expression of FBP1 after Traumatic Brain Injury and Its Role in Astrocyte Proliferation

Content Provider	Springer Nature Link
Author	Zhao, Wei Wang, Yong Shi, Wei Chen, Yang Cai, Gang Chen, Jialei Qian, Ming Xu, Wei
Copyright Year	2013
Abstract	Far upstream element binding protein 1 (FBP1) has been identified as an upstream gene of p27$^{kip1}$ (p27), which is a key regulator of mammalian cell cycle regulation and neurogenesis. To elucidate the expression and function of FBP1 in central nervous system lesion and repair, we performed a traumatic brain injury (TBI) model in adult rats. We observed that FBP1 protein level significantly reduced at day 3 after injury, and the downregulation of FBP1 was predominant in astrocytes, which were largely proliferated after injury. Furthermore, in vitro, overexpression of FBP1 was concomitant with the up-regulation of p27 and reduction of PCNA in LPS-induced astrocyte proliferation. These results suggest that a decreased level of FBP1 in brain is involved in the proliferation of glial cells after TBI.
Starting Page	687
Ending Page	694
Page Count	8
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	51
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Springer US
Publisher Date	2013-06-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Traumatic brain injury FBP1 Astrocytes Proliferation Rats Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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The Expression of FBP1 after Traumatic Brain Injury and Its Role in Astrocyte Proliferation