NDLI: Propofol-Induced Age-Different Hypocampal Long-Term Potentiation is Associated with F-Actin Polymerization in Rats

Content Provider	Springer Nature Link
Author	Li, Mingying Zhang, Xuena Wu, Anshi Wang, Zhenyuan Li, Jie Yue, Yun
Copyright Year	2014
Abstract	Elderly patients may experience a decline in cognition after a surgery performed under anesthesia. Propofol (2,6-diisopropylphenol), a common intravenous anesthetic agent, has been reported to mediate the long-term potentiation (LTP), a major form of synaptic plasticity. The present study was conducted to investigate the underlying mechanisms in young (3-month-old) and elderly (20-month-old) male rats. A decline of theta-burst stimulation (TBS)-induced LTP in the hippocampal CA1 area was found in the young rats at 72 h post-anesthesia, and this alteration almost disappeared after 2-week-recovery as compared with their age-matched control rats. On the other hand, the propofol-induced CA1 LTP reduction was persistent in the aged rats during the whole experimental process. Moreover, TBS-induced increases in CA 1 filamentous-actin (F-actin) polymerization and phospho-cofilin expression were enhanced at 72 h post-anesthesia in young rats, and this change was significantly attenuated after 2 weeks. However, in anesthetic elderly rats, the alterations in F-actin and phospho-cofilin of the CA1 region were still presented at the end of the experiments. Taken together, our results indicate that the discrepant responses between young and aged rats to propofol anesthesia may be associated with the differential polymerization of F-actin.
Starting Page	1059
Ending Page	1066
Page Count	8
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	71
Issue Number	2
e-ISSN	15590283
Language	English
Publisher	Springer US
Publisher Date	2014-10-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Propofol Anesthesia Long-term potentiation Filamentous-actin Cofilin Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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