NDLI: A Meta-analysis of the Protective Effect of Recombinant Human Erythropoietin (rhEPO) for Neurodevelopment in Preterm Infants

Content Provider	Springer Nature Link
Author	Wang, Huiping Zhang, Lan Jin, Yan
Copyright Year	2014
Abstract	The purpose of this study is to assess the efficacy and safety of recombinant human erythropoietin (rhEPO) for improving neurodevelopment outcomes in preterm infants. According to the requirements of Cochrane systematic review, a literature search was performed among PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Wan Fang Data, and VIP INFORMATION from the establishment of the database from January 1999 to December 2011. Quality assessments of clinical trials were carried out. Randomized controlled trials (RCTs) or quasi-RCTs with rhEPO in preterm infants were enrolled, and RevMan5.0 software was used for meta-analysis. Data extraction, quality assessment, and meta-analysis for the results of homogeneous studies were done by two reviewers. The trials were analyzed using weighted mean difference (WMD) for continuous data and odds ratio (OR) for dichotomous data, both kinds of data were expressed by 95 % CI. For homogenous data (P ≥ 0.10), fixed effect model was calculated. Two RCTs and 3 quasi-RCTs including 233 preterm infants (119 of treatment group and 114 of control group) were included in the analysis. The results of quality assessment were that 1 study was A, 1 was B, and 3 were C. There was evidence of a significant effect of therapeutic rhEPO on the outcomes of MDI scores [WMD = 7.77, 95 % CI (3.49–12.06), P = 0.0004], PDI scores [WMD = 3.85, 95 % CI (0.62–7.09), P = 0.02] at 18–22 months and NBNA scores [WMD = 1.96, 95 % CI (1.56–2.37), P < 0.00001] at 40 weeks of corrected gestational age. However, rhEPO had no effect on MDI <70 (OR = 0.70, 95 % CI 0.31–1.61), PDI <70 (OR = 2. 46, 95 % CI 0.94–6.45), cerebral palsy (OR = 1.08, 95 % CI 0.39–2.99), blindness (OR = 0.34, 95 % CI 0.01–8.56), and hearing loss (OR = 1.04, 95 % CI 0.06–17.15). There were no differences between groups with respect to the percentage of preterm infants with severe retinopathy of prematurity of stage III or above (OR = 1.30, 95 % CI 0.50–3.43), severe intraventricular hemorrhage of stage III or above (OR = 2. 91, 95 % CI 0.64–13.23), necrotizing enterocolitis (OR = 0.57, 95 % CI 0.13–2.54), and borderline personality disorder (OR = 1. 06, 95 % CI 0.50–2.26). The rhEPO treatment has beneficial effect on the neurodevelopment outcomes without severe adverse side effect in preterm infants.
Starting Page	795
Ending Page	802
Page Count	8
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	71
Issue Number	2
e-ISSN	15590283
Language	English
Publisher	Springer US
Publisher Date	2014-10-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Recombinant human erythropoietin Preterm Neural system Meta-analysis Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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