NDLI: Hepatoprotective Effect of Collagen Peptides From Cod Skin Against Liver Oxidative Damage In Vitro and In Vivo

Content Provider	Springer Nature Link
Author	Han, Yantao Xie, Jing Gao, Hui Xia, Yunqiu Chen, Xuehong Wang, Chunbo
Copyright Year	2014
Abstract	The objective of this study was to investigate the hepatoprotective effect of cod skin collagen peptides (CSCP), isolated from fishing industrial by-products, in vitro and in vivo. Effect of CSCP on cell proliferation of normal and H$_{2}$O$_{2}$-damaged Chang liver cells was determined by MTT assay in vitro. Two animal models, CCl$_{4}$-induced and acetaminophenum-induced acute hepatotoxicity, were established to assess the hepatoprotective effect of CSCP. Liver weight index, serum ALT and AST, antioxidant enzymes, and lipid peroxidation product were used as the markers of liver toxicity. The cell viability in the H$_{2}$O$_{2}$-treated Chang liver cells was remarkably increased when pretreated with CSCP from 100 to 1,000 µg/ml in a dose-dependent manner. CSCP pretreatment also alleviated the CCL$_{4}$-induced liver index loss, while no marked changes were found in acetaminophenum-treated mice. Furthermore, CSCP pulled down serum ALT and AST level, increased the activities of SOD and CAT, and decreased MDA in both murine models of acute liver toxicity. Pretreatment with CSCP protected liver tissue against oxidative injure in vivo and in vitro. The underlying mechanism might involve enhancement in the activities of antioxidant enzymes and reduction in the lipid peroxidation.
Starting Page	1089
Ending Page	1095
Page Count	7
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	71
Issue Number	2
e-ISSN	15590283
Language	English
Publisher	Springer US
Publisher Date	2014-10-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cod skin collagen peptides Hepatoprotective effect Oxidative damage Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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